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http://dx.doi.org/10.4333/KPS.2002.32.3.165

Injectable Gel Type Formulation of Hydrated Egg Phosphatidylcholine and Hyaluronate for Local Drug Delivery  

Kim, Sang-Gyun (Biomedical Research Center, Korea Institute of Science and Technology,Graduate School of Biotechnology, Korea University)
Chung, Hesson (Biomedical Research Center, Korea Institute of Science and Technology)
Lee, In-Hyun (Biomedical Research Center, Korea Institute of Science and Technology,Graduate School of Biotechnology Korea University)
Kang, Seung-Back (Department of Orthopedic Surgery, Boramae Hospital)
Kwon, Ick-Chan (Biomedical Research Center, Korea Institute of Science and Technology)
Sung, Ha-Chin (Graduate School of Biotechnology, Korea University)
Jeong, Seo-Young (Biomedical Research Center, Korea Institute of Science and Technology)
Publication Information
Journal of Pharmaceutical Investigation / v.32, no.3, 2002 , pp. 165-172 More about this Journal
Abstract
Injectable gel composed of egg phosphatidylcholine (egg PC), hyaluronate (HA) and water was formulated for local drug delivery. The lamellar liquid crystalline structure of the egg PC/water system did not change by adding HA in the formulation. However, egg PC/HA/water gel was more resistant to erosion than the egg PC/water gel. The egg PC/HA/water and egg PC/water gels containing model drugs, tetracycline and sudan IV were prepared to perform in vitro and in vivo drug release experiments. In vitro release of tetracycline was sustained in the gel type formulations. The release rate of hydrophobic sudan IV was extremely slow. More than 99% of sudan IV remained inside the gel after 5 days. In vivo release of drugs from the air pouch model in Balb/c mice shows that lipophilic sudan IV remained for more than 10 days whereas tetracycline remained for 1 day in the pouch. The compatibility of the gels was also examined by histopathology. The gels did not cause any adverse inflammatory effect in the air pouch.
Keywords
Injectable gel; Sustained release; Egg phosphatidylcholine; Hyaluronate;
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  • Reference
1 T.P. Johnston, M.A. Punjabi and C.J. Froelich, Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice, Pharm. Res., 9, 42 -434 (1992)
2 A. Paavola, J. Yliruusi and P. Rosenberg, Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels, J. Control. Rel., 52, 169-178 (1998)   DOI   ScienceOn
3 T. Kitoh, K. Mizuno, M. Nagasawa and T. Otagin, Anesthetic management of a patient with hyperkalemic tubular acidosis, Masui, Jap.e J. Anesthesiology, 42, 1671-1673 (1993)
4 H.J. McQuay, R.A. Moore, C. Eccleston, S. Morley and A.C. Williams, Systematic review of outpatient services for chronic pain control, Health Technology Assessment 1, 1-135 (1997)
5 R. Bodmeier and H. Chen, Indomethacin polymeric nanosuspensions prepared by microfluidization, J. Control. Rel., 12, 223-233 (1990)   DOI   ScienceOn
6 E. Mathiowitz, J.S. Jacob, Y.S. Jong, G.P. Carino, D.E. Chic- kering, P. Chaturvedi, C.A. Santos, K. Vijayaraghavan, S. Montgomery, M. Bassett and C. Morrell, Biologically erodable microspheres as potential oral drug delivery systems, Nature, 386, 410-414 (1997)   DOI   ScienceOn
7 R. Herrero-Vanrell and M. F. Refojo, Biodegradable microspheres for vitreoretinal drug delivery, Adv. Drug Del. Rev., 52, 516 (2001)
8 Z. Yang, P. Birkenhauer, F. Julmy, D. Chickering and P. J. Ranieri, Sustained release of heparin from polymeric particles for inhibition of human vascular smooth muscle cell proliferation, J. Control. Rel., 60, 269-277 (1999)   DOI   ScienceOn
9 J.M. Malinovsky, P. Le Corre, J.F. Meunier, F. Chevanne, M. Pinaud, R. Leverge and F Legros, A dose response study of epidural liposomal bupivacaine in rabbits, J. Control. Rel., 60, 111-119 (1999)   DOI   ScienceOn
10 G. Gregoriadis and A.T. Florence, Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential, Drugs, 45, 15-28 (1993)
11 E.S. Park, M. Maniar and J.C. Shah, Biodegradable polyanhydride devices of cefazolin sodium, bupivacaine, and taxol for local drug delivery: Preparation, and kinetics and mechanism of in vitro release, J. Control. Rel., 52, 179-189 (1998)   DOI   ScienceOn
12 R. Koynova and M. Caffrey, Phases and phase transitions of the phosphatidylcholines, Biochim. Biophys. Acta, 1376, 91-145 (1998)   DOI   ScienceOn
13 T.P. Johnston and S.C. Miller, Inulin disposition following intramuscular administration of an inulin/poloxamer gel matrix, Parenter. Sci. Technol., 43, 279-286 (1989)
14 A.D. Sedgwick, Y.M. Sin, J.C. Edwards and D. A. Willoughby, Increased inflammatory reactivity in newly formed lining tissue, J. Pathology, 141, 483-495 (1983)   DOI
15 Y. Liang, M.B. Denton and R.B. Bates, Stability studies of tetracycline in methanol solution, J. Chromatography A, 827, 45-55 (1998)   DOI   ScienceOn
16 T. Murakami, H. Higaki, Y. Sawae, N. Ohtsuki, S. Moriyama and Y. Nakanishi, Adaptive multimode lubrication in natural synovial joints and artificial joints, J. Eng. Med., 212, 23-35 (1998)   DOI   ScienceOn
17 E.L. Liljensten, A.G. Attaelmanan, C. Larsson, H. LjusbergWahren, N. Danielsen, J.M. Hirsch and P. Thomsen, Hydroxyapatite granule/carrier composites promote new bone forma- tion in cortical defects, Clin. Implant. Dent. Relat. Res., 2, 50-59 (2000)   DOI   ScienceOn
18 A. Paavola, P. Tarkkila, M. Xu, T. Wahlstrom, J. Yliruusi and P. Rosenberg, Controlled release gel of ibuprofen and lidocaine in epidural use analgesia and systemic absorption in pigs, Pharm Res., 15, 482-487 (1998)   DOI   ScienceOn
19 J. Sandelin, A. Harilainen, H. Crone, P. Hamberg, B. Forsskahl and G. Tamelander, Local NSAID gel (eltenac) in the treat- ment of osteoarthritis of the knee. A double blind study comparing eltenac with oral diclofenac and placebo gel, Scandinavian J. Rheumatology, 26, 287-292 (1997)
20 L.A. Guzman, V. Labhasetwar, C. Song, Y. Jang, A.M. Lincoff, R. Levy and E.J. Topol, Local intraluminal infusion of biode- gradable polymeric nanoparticles: a novel approach for prolonged drug delivery after balloon angioplasty, Circulation, 94, 1441-1448 (1996)   DOI   ScienceOn
21 M. Winterhalter and D.D. Lasic, Liposome stability and formation: Experimental parameters and theories on the size distribution, Chem. Phys. Lipids, 64, 35-43 (1993)   DOI   ScienceOn
22 D. Campoccia, P. Doherty, M. Radice, P. Brun, G. Abatangelo and D. F. Williams, Semisynthetic resorbable materials from hyaluronan esterification, Biomaterials, 19, 2101-2127 (1998)   DOI   ScienceOn
23 A. Cheng, B. Hummel, H. Qiu and M. Caffrey, A simple mechanical mixer for small viscous lipid-containing samples, Chem. Phys. Lipids, 95, 1121 (1998)
24 P.H. Wooley. R. Morren, J. Andary, S. Sud, S.Y. Yang, L. Mayton, D. Markel, A. Sieving and S. Nasser, Inflammatory responses to orthopaedic biomaterials in the murine air pouch, Biomaterials, 2, 517-526 (2002)
25 L.A. Mitscher, The Chemistry of the Tetracycline Antibiotics, Medicinal Research Series Vol. 9. Marcel Dekker Inc., p. 103 (1978)
26 Y. Liang, M. B. Denton and R. B. Bates, Stability studies of tetracycline in methanol solution, J. Chromatography A, 827, 45-55 (1998)   DOI   ScienceOn