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http://dx.doi.org/10.4333/KPS.2002.32.2.107

Formulation and Evaluation of Melatonin Plasters  

Gwak, Hye-Sun (College of Pharmacy, Dongduk Women's University)
Kim, Seung-Ung (College of Pharmacy, Dongduk Women's University)
Chun, In-Koo (College of Pharmacy, Dongduk Women's University)
Publication Information
Journal of Pharmaceutical Investigation / v.32, no.2, 2002 , pp. 107-112 More about this Journal
Abstract
To investigate the feasibility of developing a novel melatonin plaster, the effects of vehicles and drug loading dose on the in vitro permeation of melatonin across dorsal hairless mouse skin from pressure-sensitive adhesive (PSA) matrices were examined. Vehicles employed were propylene glycol laurate (PGL), propylene glycol monocaprylate (PGMC) and diethylene glycol monoethyl ether (DGME). Among PSAs used, only $Duro-Tak^{\circledR}$ 87-2196 showed a good peeling property. The release from $Duro-Tak^{circledR}$ 87-2196 was proportional to the square root of time, and dose-dependent. The fluxes increased as the loading dose increased over the doses under solubility. The relatively high permeation flux $(3.03{\pm}1.37\;{\mu}g/cm^2/hr)$ was obtained when using PGMC at the melatonin loading dose of $45\;mg/140\;cm^2$. Lag time was not affected by the vehicles used but by the thickness spread. The melatonin plasters prepared using PGMC showed a good adhesive property onto skin, and showed no crystal formation.
Keywords
Melatonin; Pressure-sensitive adhesive matrices; Vehicles; Release; Permeation;
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