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http://dx.doi.org/10.4333/KPS.2002.32.2.103

A Release Test for Gels Containing Ketoprofen  

Kim, Ho-Jeong (Department of Drug Evaluation, Korea Food and Drug Administration)
Yun, Mi-Ok (Department of Drug Evaluation, Korea Food and Drug Administration)
Lee, Su-Jung (Department of Drug Evaluation, Korea Food and Drug Administration)
Choi, Hyun-Chul (Department of Drug Evaluation, Korea Food and Drug Administration)
Kim, Ji-Young (Department of Drug Evaluation, Korea Food and Drug Administration)
Kim, In-Wha (Institute of Pharmaceutical Research, College of Pharmacy, Seoul National University)
Shim, Chang-Koo (Institute of Pharmaceutical Research, College of Pharmacy, Seoul National University)
Kang, Shin-Jung (Department of Drug Evaluation, Korea Food and Drug Administration)
Publication Information
Journal of Pharmaceutical Investigation / v.32, no.2, 2002 , pp. 103-106 More about this Journal
Abstract
A method that describes the determination of the in vitro release of ketoprofen from gels was suggested. The experimental system of the method consists of a Franz diffusion cell, which contains a pH 7.4 phosphate buffer as a receptor medium, and a $70\;{\mu}m$ mesh woven nylon membrane as a diffusion barrier. Under the given condition of the system, the diffusion of ketoprofen across the membrane was rapid enough that the apparent release profile of ketoprofen obtained from the present method could represent the release of the drug from gel preparations. The release of ketoprofen in the present method was reproducible, and the rate increased in proportion to the concentration of ketoprofen in the gel. These suggest that the present method is applicable to the quality evaluation of gel preparations containing ketoprofen.
Keywords
Ketoprofen; gels; in vitro release; Franz diffusion cell; nylon membrane;
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