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Effect of Insulin Resistance on the Metabolism of Periparturient Dairy Cattle  

Kim, Jin-Wook (Dept. of Animal Bioscience (Insti. of Agric. & Life Sci.), Gyeongsang National Univ.)
Publication Information
Journal of agriculture & life science / v.44, no.5, 2010 , pp. 65-74 More about this Journal
Abstract
Dairy cow undergoes major adaptations in glucose and lipid metabolism to meet fetal and mammary nutrient requirements during the periparturient period. These adaptations are characterized by major changes in response to the homeostatic signal of insulin. In response to insulin, fatty acids are mobilized to meet energy demand. And cow develop insulin resistance during the late prepartum period to facilitate glucose sparing for the fetus and mammary gland. Insulin resistance is an important adaptation and may be partly responsible for the large increase in plasma nonesterified fatty acid (NEFA) that occurs prior to parturition and coincides with the characteristic decrease in dry matter intake (DMI). Modulation of insulin resistance by administration of thiazolidinedione (TZD) during the periparturient period, likely through the activation of $PPAR{\gamma}$, has substantial potential to minimize energy and immune-related metabolic disorders, and thus may result in increased productivity and improved health of dairy cows.
Keywords
Insulin esistance; Periparturient period; Dairy cow;
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