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http://dx.doi.org/10.5757/JKVS.2007.16.1.052

Single Interaction Force of Biomolecules Measured with Picoforce AFM  

Jung, Yu-Jin (Center for Integrated Molecular Systems, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology)
Park, Joon-Won (Center for Integrated Molecular Systems, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology)
Publication Information
Journal of the Korean Vacuum Society / v.16, no.1, 2007 , pp. 52-57 More about this Journal
Abstract
The interaction force between biomolecules(DNA-DNA, antigen-antibody, ligand-receptor, protein-protein) defines not only biomolecular function, but also their mechanical properties and hence bio-sensor. Atomic force microscopy(AFM) is nowadays frequently applied to determine interaction forces between biological molecules and biomolecular force measurements, obtained for example using AFM can provide valuable molecular-level information on the interactions between biomolecules. A proper modification of an AFM tip and/or a substrate with biomolecules permits the direct measurement of intermolecular interactions, such as DNA-DNA, protein-protein, and ligand-receptor, etc. and a microcantilever-based sensor appeared as a promising approach for ultra sensitive detection of biomolecular interactions.
Keywords
Atomic Force Microscopy; Biomolecules; Force Measurements; Inter-and Intra-Molecular Interactions; Microcantilever-Based Sensor;
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1 S. Allen, S. M. Rigby-Singleton, H. Harris, M. C. Davies, P. O'Shea, Biochem. Soc. Trans. 31, 1052 (2003)   DOI   ScienceOn
2 U. Bockelmann, B. Essevaz-Roulet, F. Heslot, Phys. Rev. E. 58, 2836 (1998)
3 T. Strunz, K. Oroszlan, R. Schafer, H. J. Guntherodt, Proc. Natl. Acad. Sci. U.S.A. 96, 11277 (1999)
4 G. U. Lee, D. A. Kidwell, R. J. Colton, Langmuir 10, 354 (1994)   DOI   ScienceOn
5 T. V. Ratto, R. E. Rudd, K. C. Langry, R. L. Balhorn, M. W. McElfresh, Langmuir 22, 1749 (2006)   DOI   ScienceOn
6 Rief, M.; Clausen-Schaumann, H.; Gaub, H. E. Nat. Struct. Biol. 6, 346 (1999)   DOI   ScienceOn
7 L. Li, S. Wetzel, A. Plückthun, J. M. Fernandez, Biophys. J. 90, L30 (2006)   DOI   ScienceOn
8 V. Dupres, F. D. Menozzi, C. Locht, B. H. Clare, N. L. Abbott, S. Cuenot, C. Bompard, D. Raze, and Y. F. Dufrene, Nature Methods 2, 515 (2005)   DOI   ScienceOn
9 M. S. Z. Kellermayer, S. B. Smith, H. L. Granzier, C. Bustamante, Science 276, 1112 (1997)   DOI   ScienceOn
10 H. Clausen-Schaumann, M. Seitz, R. Krautbauer, H. E. Gaub, Curr. Opin. Chem. Biol. 4, 524 (2000)   DOI   ScienceOn
11 H. Clausen-Schaumann, M. Rief, C. Tolksdorf, H. E. Gaub, Biophys. J. 78, 1997 (2000)   DOI   ScienceOn
12 R. Merkel, P. Nassoy, A. Leung, E. Evans, K. Ritchie, Nature 397, 60 (1999)
13 P. M. Williams, S. B. Fowler, R. B. Best, J. L. Toca-Herrera, K. A. Scott, A. Steward, J. Clarke, Nature 422, 446 (2003)   DOI   ScienceOn
14 T. Hugel, and M. Seitz, Macromol. Rapid. Commun. 22, 989 (2001)   DOI   ScienceOn
15 C. A. Savran, S. M. Knudsen, A. D. Ellington, and S. R. Manalis, Anal. Chem. 76, 3194 (2004)   DOI   ScienceOn
16 G. Hummer, A. Szabo, Acc. Chem. Res. 38, 504 (2005)   DOI   ScienceOn
17 A. Berquand, N. Xia, D. G. Castner, B. H. Clare, N. L. Abbott, V. Dupres, Y. Adriaensen, Y. F. Dufrene, Langmuir 21, 5517, (2005)   DOI   ScienceOn
18 P. Hinterdorfer, H. J. Gruber, F. Kienberger, G. Kada, C. Riener, C. Borken, and H. Schindler, Colloids Surf. B: Biointerfaces 23, 115 (2002)   DOI   ScienceOn
19 M. Rief, M. Gautel, F. Oesterhelt, J. M. Fernandez, H. E. Gaub, Science 276, 1109 (1997)   DOI   ScienceOn
20 P. E. Marszalek, H. Lu, M. Carrion-Vazquez, A. F. Oberhauser, K. Schulten, J. M. Fernandez, Nature 402, 100 (1999)   DOI   ScienceOn
21 W. K. Zhang, and X. Zhang, Prog. Polym. Sci. 28, 1271 (2003)   DOI   ScienceOn
22 A. Janshoff, M. Neitzert, Y. Oberdörfer, and H. Fuchs, Angew. Chem. Int. Ed. 39, 3212 (2000)   DOI   ScienceOn
23 G. A. Campbell, and R. Mutharasan, Anal. Chem. 78, 2328 (2006)   DOI   ScienceOn
24 V. K. Yadavalli, J. G. Forbes, and K. Wang, Langmuir 22, 6969, (2006)   DOI   ScienceOn