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Functional MRI of Language: Difference of its Activated Areas and Lateralization according to the Input Modality  

Ryoo, Jae-Wook (Department of Radiology, Samsung Medical Center)
Cho, Jae-Min (Department of Radiology, Gyeongsang National University School of Medicine)
Choi, Ho-Chul (Department of Radiology, Gyeongsang National University School of Medicine)
Park, Mi-Jung (Department of Radiology, Gyeongsang National University School of Medicine)
Choi, Hye-Young (Department of Radiology, Gyeongsang National University School of Medicine)
Kim, Ji-Eun (Department of Radiology, Gyeongsang National University School of Medicine)
Han, Heon (Department of Radiology, Kangwon National University College of Medicine)
Kim, Sam-Soo (Department of Radiology, Kangwon National University College of Medicine)
Jeon, Yong-Hwan (Department of Radiology, Kangwon National University College of Medicine)
Khang, Hyun-Soo (Department of Radiology Technology, Eulji University College of Health Sciences)
Publication Information
Investigative Magnetic Resonance Imaging / v.15, no.2, 2011 , pp. 130-138 More about this Journal
Abstract
Purpose : To compare fMRIs of visual and auditory word generation tasks, and to evaluate the difference of its activated areas and lateralization according to the mode of stimuli. Materials and Methods : Eight male normal volunteers were included and all were right handed. Functional maps were obtained during auditory and visual word generation tasks in all. Normalized group analysis were performed in each task and the threshold for significance was set at p<0.05. Activated areas in each task were compared visually and statistically. Results : In both tasks, left dominant activations were demonstrated and were more lateralized in visual task. Both frontal lobes (Broca's area, premotor area, and SMA) and left posterior middle temporal gyrus were activated in both tasks. Extensive bilateral temporal activations were noted in auditory task. Both occipital and parietal activations were demonstrated in visual task. Conclusion : Modality independent areas could be interpreted as a core area of language function. Modality specific areas may be associated with processing of stimuli. Visual task induced more lateralized activation and could be a more useful in language study than auditory task.
Keywords
Brain; Magnetic resonance (MR); Functional; Language;
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1 Hart J Jr, Gordon B. Delineation of single-word semantic comprehension deficits in aphasia, with anatomical correlation. Ann Neurol 1990;27:226-231   DOI   ScienceOn
2 Wise R, Chollet F, Hadar U, Friston K, Hoffner E, Frackowiak R. Distribution of cortical neural networks involved in word comprehension and word retrieval. Brain 1991;114:1803-1817   DOI   ScienceOn
3 Oldfield RC. The assessment and analysis of handedness: the edinburgh inventory. Neuropsychologia 1971;9:97-113   DOI   ScienceOn
4 Frost JA, Binder JR, Possing ET, Bellgowan TA, Hammeke TA. Stimulus novelty affects superior temporal gyrus activation. Neuroimage 1998;7:S377   DOI   ScienceOn
5 Warburton E, Wise RJS, Price CJ, et al. Noun and verb retrieval by normal subjects studies with PET. Brain 1996;119:159-179   DOI   ScienceOn
6 Frith CD, Friston KJ, Liddle PF, Frackowiak RSJ. A PET study of word finding. Neuropsychologia 1991;29:1137-1148   DOI   ScienceOn
7 Frith CD, Friston KJ, Liddle PF, Frackowiak RSJ. Willed action and the prefrontal cortex in man: a study with PET. Proc R Soc Lond B Biol Sci 1991;244:241-246   DOI   ScienceOn
8 Paulesu E, Frith CD, Frackowiak RS. The neural correlates of the verbal component of working memory. Nature 1993;362:342-345   DOI
9 Price CJ, Wise RJ, Frackowiak RS. Demonstrating the implicit processing of visually presented words and pseudowords. Cereb Cortex 1996;6:62-70   DOI
10 Binder JR, Frost JA, Hammeke TA, Cox RW, Rao SM, Prieto T. Human brain language areas identified by functional magnetic resonance imaging. J Neurosci 1997;17:353-362
11 정희영, 김재형, 신태민 등. 1.5 T 자기공명영상을 이용한 사람 뇌의 언어관련기능의 Mapping: 운동성 언어기능을 중심으로. 대한방사선의학회지 1998;38:205-210
12 유인규, 장기현, 송인찬 등. EPI 기법을 이용한 운동성 뇌언어중추의 기능적 자기공명영상. 대한방사선의학회지 1998;38:957-964
13 유재욱, 나동규, 변홍식 등. 언어영역의 기능적 자기공명영상. 대한자기공명의과학회지 1999;3:53-59
14 유이령, 안국진, 김 태, 이재문. 기능적 자기공명영상을 이용한 뇌의 우세 운동성 언어 중추의 결정: 시각과 청각적 자극 방법의 비교. 대한방사선의학회지 1999;41:1085-1090
15 Schaffler L, Luders HO, Dinner DS, Lesser RP, Chelune GJ. Comprehension deficits elicited by electrical stimulation of Broca's area. Brain 1993;116:695-715   DOI   ScienceOn
16 Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME. Positron emission tomographic studies for the cortical anatomy of single word processing. Nature 1988;331:585-589   DOI   ScienceOn
17 Rothwell JC, Day BF, Thompson PD. Some experiences of techniques for stimulation of human cerebral motor cortex through the scalp. Neurosurgery 1987;20:156-163
18 Toga and Mazziota. Brain mapping: the system. Academic press. Chapter 14 1997:301-328
19 Ojemann GA. Cortical organization of language. J Neurosci 1991;11:2281-2287
20 McClelland JL, Rumelhart DE. An interactive action model of context effects in letter perception: an account of basic findings. Psychol Rev 1981;88:375-407
21 Levelt WJM. Speaking: from intention to articulation. Cambridge: MIT press, 1997
22 Seidenberg MS, McClelland JL. A distributed, developmental model of word recognition and naming. Psychol Rev 1989;96:523-568
23 Marshall JC, Newcombe F. Patterns of paralexia: a psycholinguistic approach. J Psycholinguist Res 1973;2:175-199   DOI   ScienceOn
24 McCarthy G, Blamire AM, Rothman DL, Gruetter R, Shulman RG. Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proc Natl Acad Sci 1993;90:4952-4956   DOI   ScienceOn
25 Moore CJ, Price CJ. Three distinct ventral occipitotemporal regions for reading and object naming. Neuroimage 1999;10:181-192   DOI   ScienceOn
26 Binder JR. Functional magnetic resonance imaging: language mapping. Neurosurgery Clin North Am 1997;8:383-392
27 Lichtheim L. On aphasia. Brain 1885;7:433-484
28 유재욱, 나동규, 변홍식 등. 기능적 자기공명영상을 이용한 언어기능의 편재화: Wada검사와의 비교에 관한 예비연구. 대한방사선의학회지 1999;40:821-827
29 Demonet JF, Chollet F, Ramsay S, et al. The anatomy of phonological and semantic processing in normal subjects. Brain 1992;15:1753-1768
30 Damasio H, Grabowski TJ, Tranel D, Hichwa RD, Damasio AR. A neural basis for lexical retrieval. Nature 1996;380:499-505   DOI   ScienceOn
31 Gorno-Tempini ML, Price CJ, Josephs O, et al. The neural systems sustaining face and proper-name processing. Brain 1998;121:2103-2118   DOI
32 Mummery CJ, Patterson K, Hodges JR, Price CJ. Functional neuroanatomy of the semantic system: divisible by what? J Cogn Neurosci 1998;10:766-777   DOI   ScienceOn
33 Desmond JE, Sum JM, Wagner AD, et al. Functional MRI measurement of language lateralization in Wada-tested patients. Brain 1995;118:1411-1419   DOI   ScienceOn
34 Binder JR, Swanson SJ, Hammeke TA, et al. Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology 1996;46:978-984   DOI
35 Costello AL, Warrington EK. Dynamic aphasia: the selective impairment of verbal planning. Cortex 1989;25:103-114
36 van der Kallen BFW, Morris GL, Yetkin FZ, van Erning LJTO, Thijssen HOM, Haughton VM. Hemispheric language dominance studied with functional MR: preliminary study in healthy volunteers and patients with epilepsy. AJNR Am J Neuroradiol 1998;19:73-77
37 Price CJ. The anatomy of language: contributions from functional neuroimaging. J Anat 2000;197:335-359   DOI   ScienceOn
38 Chee MW, O'Craven KM, Bergida R, Rosen BR, Savoy RL. Auditory and visual word processing studied with fMRI. Hum Brain Mapp 1999;7(1):15-28   DOI   ScienceOn
39 Carpentier A, Pugh KR, Westerveld M, et al. Functional MRI of language processing: dependence on input modality and temporal lobe epilepsy. Epilepsia 2001;42:1241-1254   DOI   ScienceOn
40 Damasio AR, Geschwind N. The neural basis of language. Annu Rev Neurosci 1984;7:127-147   DOI   ScienceOn
41 Mesulam MM. Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann Neurol 1990;28:597-613   DOI   ScienceOn
42 Kertesz A, Sheppard A, MacKenzie R. Localization in transcortical sensory aphasia. Arch Neurol 1982;39:475-478   DOI   ScienceOn
43 Alexander MP, Hiltbrunner B, Fischer RS. Distributed anatomy of transcortical sensory aphasia. Arch Neurol 1989;46:885-892   DOI   ScienceOn
44 Geshwind N. Disconnexion syndromes in animals and man. I. Brain 1965;88:237-294   DOI   ScienceOn