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http://dx.doi.org/10.13104/jksmrm.2014.18.2.133

Magnetic Resonance Imaging Factors Predicting Re-excision in Breast Cancer Patients Having Undergone Conserving Therapy  

Jang, Mijung (Department of Radiology, Seoul National University Bundang Hospital)
Kim, Sun Mi (Department of Radiology, Seoul National University Bundang Hospital)
Yun, Bo La (Department of Radiology, Seoul National University Bundang Hospital)
Kim, Sung-Won (Department of Surgery, Seoul National University Bundang Hospital)
Kang, Eun Young (Department of Surgery, Seoul National University Bundang Hospital)
Park, So Yeon (Department of Pathology, Seoul National University Bundang Hospital)
Kim, Jee Hyun (Department of Oncology, Seoul National University Bundang Hospital)
Kim, Yeongmi (Department of Radiology, Samsung Changwon Hospital, Sungkyunkwan University)
Ahn, Hye Shin (Department of Radiology, Chung-Ang University Hospital)
Publication Information
Investigative Magnetic Resonance Imaging / v.18, no.2, 2014 , pp. 133-143 More about this Journal
Abstract
Purpose : The aim of this study was to determine the magnetic resonance imaging (MRI) features associated with re-excision due to the presence of a positive margin after breast conserving therapy (BCT) in breast cancer patients. Materials and Methods: We reviewed the records of 286 consecutive breast cancer patients who received BCT between January 2006 and December 2007. Among 246 patients who had undergone BCT, 38 (15.4%) underwent immediate further surgery due to positive margin status. We analyzed the MRI findings using ${\chi}^2$ test, Fisher's exact test and t tests. Multivariate logistic regression was conducted for prediction of re-excision. Results: Tumor size (p < 0.001), lesion multiplicity (p = 0.003), and non-mass-like enhancement (NMLE) type on MRI (p < 0.001) were associated with margin involvement in BCT. On preoperative MRI, larger size (${\geq}5cm$) (odds ratio = 2.96), NMLE (odds ratio = 3.81), and multifocal lesions (odds ratio = 2.54) were positively associated with re-excision. In cases involving NMLE, segmental distribution was associated with a greater likelihood of immediate re-excision. Conclusion: Larger size, multiplicity, and NMLE on MRI are significantly associated with re-excision after BCT in breast cancer patients. For NMLE lesions, the segmental distribution pattern was predictive of re-excision.
Keywords
Breast; Breast neoplasm; Conservation therapy; Diagnosis; Magnetic resonance imaging (MRI);
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