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http://dx.doi.org/10.13104/jksmrm.2013.17.3.207

Magnetic Resonance Imaging of Breast Cancer Patients with BRCA Mutation  

Chung, Sun Young (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Cha, Joo Hee (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Kim, Hak Hee (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Shin, Hee Jung (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Kim, Hyun Ji (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Chae, Eun Young (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Shin, Ji Eun (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Choi, Woo Jung (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Hong, Min Ji (Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan)
Ahn, Sei Hyun (Department of General Surgery, Asan Medical Center, College of Medicine, University of Ulsan)
Lee, Jong Won (Department of General Surgery, Asan Medical Center, College of Medicine, University of Ulsan)
Jung, Kyung Hae (Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan)
Publication Information
Investigative Magnetic Resonance Imaging / v.17, no.3, 2013 , pp. 207-214 More about this Journal
Abstract
Purpose : To evaluate the MRI findings of breast cancer with BRCA mutation. Materials and Methods: We collected information of the breast cancer patients who underwent the test for BRCA gene mutation as well as preoperative breast MRI from January 2007 to December 2010. A total of 185 patients were enrolled; 33 of these patients had BRCA mutations and 152 patients did not. Among them, a total of 231 breast cancers were detected. Images of the 47 breast cancers with BRCA mutation and of the 184 breast cancers without mutations were evaluated to compare the morphologic and enhancement features on MRI. Results: With MR imaging, there were no significant difference in morphologic characteristic between two groups. However, enhancement pattern in the group with BRCA mutation were more likely to have persistent enhancement (p < 0.233), and LN metastasis was more common in breast cancers without BRCA mutation. Breast cancers with BRCA 2 mutation tend to show more persistent enhancement pattern than BRCA 1 mutation. Conclusion: In breast cancer patients with BRCA mutation, MRI didn't show significant difference in morphologic characteristics, however breast cancers with BRCA gene mutation carriers tend to have benign morphologic features on MRI, such as Type 1 kinetic curve enhancement.
Keywords
BRCA mutation; Breast cancer; Magnetic resonance imaging (MRI);
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