Browse > Article

Ferucarbotran-Enhanced Hepatic MRI at 3T Unit: Quantitative and Qualitative Comparison of Fast Breath-hold Imaging Sequences  

Cho, Kyung-Eun (Department of Radiology and Institute of Radiological Science, Yonsei University College of Medicine, Gangnam Severance Hospital)
Yu, Jeong-Sik (Department of Radiology and Institute of Radiological Science, Yonsei University College of Medicine, Gangnam Severance Hospital)
Chung, Jae-Joon (Department of Radiology and Institute of Radiological Science, Yonsei University College of Medicine, Gangnam Severance Hospital)
Kim, Joo-Hee (Department of Radiology and Institute of Radiological Science, Yonsei University College of Medicine, Gangnam Severance Hospital)
Kim, Ki-Whang (Department of Radiology and Institute of Radiological Science, Yonsei University College of Medicine, Gangnam Severance Hospital)
Publication Information
Investigative Magnetic Resonance Imaging / v.14, no.1, 2010 , pp. 31-40 More about this Journal
Abstract
Purpose : To compare the relative values of various fast breath-hold imaging sequences for superparamagnetic iron-oxide (SPIO)-enhanced hepatic MRI for the assessment of solid focal lesions with a 3T MRI unit. Materials and Methods : 102 consecutive patients with one or more solid malignant hepatic lesions were evaluated by spoiled gradient echo (GRE) sequences with three different echo times (2.4 msec [GRE_2.4], 5.8 msec [GRE_5.8], and 10 msec [GRE_10]) for $T2^*$-weighted imaging in addition to T2-weighted turbo spin echo (TSE) sequence following intravenous SPIO injection. Image qualities of the hepatic contour, vascular landmarks and artifacts were rated by two independent readers using a four-point scale. For quantitative analysis, contrast-to-noise ratio (CNR) was measured in 170 solid focal lesions larger than 1 cm (107 hepatocellular carcinomas, nine cholangiocarcinomas and 54 metastases). Results : GRE_5.8 showed the highest mean points for hepatic contour, vascular anatomy and imaging artifact presence among all of the subjected sequences (p<0.001) and was comparable (p=0.414) with GRE_10 with regard to lesion conspicuity. The mean CNRs were significantly higher (p<0.001) in the following order: GRE_10 ($24.4{\pm}14.5$), GRE_5.8 ($14.8{\pm}9.4$), TSE ($9.7{\pm}6.3$), and GRE_2.4 ($7.9{\pm}6.4$). The mean CNRs of CCCs and metastases were higher than those of HCCs for all imaging sequences (p<0.05). Conclusion : Regarding overall performances, GRE using a moderate echo time of 5.8 msec can provide the most reliable data among the various fast breath-hold SPIO-enhanced hepatic MRI sequences at 3T unit despite the lower CNR of GRE_5.8 compared to that of GRE_10.
Keywords
Liver neoplasm; Magnetic resonance (MR); Superparamagnetic iron oxide (SPIO);
Citations & Related Records
연도 인용수 순위
  • Reference
1 Zapparoli M, Semelka RC, Altun E, et al. 3.0-T MRI evaluation of patients with chronic liver diseases : initial observations. Magn Reson Imaging 2008;26:650-660   DOI   ScienceOn
2 Schneider G, Reimer P, Mabmann A, Kirchin MA, Morana G, Grazioli G. Contrast agents in abdominal imaging-current and future directions. Top Magn Reson Imaging 2005;16:107-124   DOI   ScienceOn
3 Kanematsu M, Itoh K, Matsuo M, et al. Malignant hepatic tumor detection with ferumoxides-enhanced MR imaging with a 1.5-T system: comparison of four imaging pulse sequences. J Magn Reson Imaging 2001;13:249-257   DOI   ScienceOn
4 Ramalho M, Altun E, Here′dia V, Zapparoli M, Semelka R. Liver MR imaging: 1.5T versus 3T. Magn Reson Imaging Clin N Am 2007;15:321-347   DOI   ScienceOn
5 Yoshikawa T, Mitchell DG, Hirota S, et al. Gradient- and spin-echo T2-weighted imaging for SPIO-enhanced detection and characterization of focal liver lesions. J Magn Reson Imaging 2006;23:712-719   DOI   ScienceOn
6 Kim T, Murakami T, Hori M, Onishi H, Tomoda K, Nakamura H. Effect of superparamagnetic iron oxide on tumor-to-liver contrast at $T2^{*}$-weighted gradient-echo MRI: comparison between 3.0T and 1.5T MR systems. J Magn Reson Imaging 2009;29:595-600   DOI   ScienceOn
7 Tanimoto A, Yuasa Y, Shinmoto H, et al. Superparamagnetic iron oxide-mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence and Kupffer cell function. Radiology 2002;222:661-666   DOI   ScienceOn
8 Tanimoto A, Oshio K, Suematsu M, Pouliquen D, Stark DD. Relaxation effects of clustered particles. J Magn Reson Imaging 2001;14:72-77   DOI   ScienceOn
9 Tang Y, Yamashita Y, Arakawa A, et al. Detection of hepatocellular carcinoma arising in cirrhotic livers: comparison of gadolinium and ferumoxides-enhanced MR imaging. AJR Am J Roentgenol 1999;172:1547-1554   DOI
10 Matsuo M, Kanematsu M, Itoh K, et al. Detection of malignant hepatic tumors with ferumoxides-enhanced MRI: Comparison of five gradient-recalled echo sequences with different TEs. AJR Am J Roentgenol 2004;182:235-242   DOI
11 Ward J, Chen F, Guthrie JA, et al. Hepatic lesion detection after superparamagnetic iron oxide enhancement: comparison of five T2-weighted sequences at 1.0 T by using alternativefree response receiver operating characteristic analysis. Radiology 2000;214:159-166   DOI
12 Kurokawa H, Togami I, Tsunoda M, Hiraki Y. Experimental study of fast and ultrafast T2-weighted imaging sequences using AMI-25 superparamagnetic iron oxide (SPIO). Acta Med Okayama 2001;55:41-50
13 Kumano S, Murakami T, Kim T, et al. Using superparamagnetic iron oxide-enhanced MRI to differentiate metastatic hepatic tumors and nonsolid benign lesions. AJR Am J Roentgenol 2003;181:1335-1339   DOI
14 Tanimoto A, Yuasa Y, Shinmoto H, et al. Superparamagnetic iron oxide-mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence effects and Kupffer cell function. Radiology 2002;222:661-666   DOI   ScienceOn
15 Chang JM, Lee JM, Lee MW, et al. Superparamagnetic iron oxide-enhanced liver magnetic resonance imaging-comparison of 1.5T and 3.0T imaging for detection of focal malignant liver lesions. Invest Radiol 2006;41:168-174   DOI   ScienceOn
16 Elizondo G, Weissleder R, Stark DD, et al. Hepatic cirrhosis and hepatitis: MR imaging enhanced with superparamagnetic iron oxide. Radiology 1990;174:797-801   DOI
17 Zech CJ, Herrmann KA, Dietrich O, Horger W, Reiser MF, Schoenberg SO. Black-blood diffusion-weighted EPI acquisition of the liver with paraller imaging. Comparison with a standard T2-weighted sequence for detection of focal liver lesions. Invest Radiol 2008;43:261-266   DOI   ScienceOn
18 Kuwatsuru R, Brasch RC, Muhler A, et al. Definition of liver tumors in the presence of diffuse liver disease: comparison of findings at MR imaging with positive and negative contrast agents. Radiology 1997;202:131-138   DOI
19 von Falkenhausen MM, Lutterbey G, Morakkabati-Spitz N, et al. High-field-strength MR imaging of the liver at 3.0T: Intraindividual comparative study with MR imaging at 1.5T. Radiology 2006;241:156-166   DOI   ScienceOn
20 Nakada T. Clinical Experience on 3.0T systems in Niigata, 1996 to 2002. Invest Radiol 2003;38:377-384
21 Ward J, Guthrie JA, Wilson D, et al. Colorectal hepatic metastases: detection with SPIO-enhanced breath-hold MR imaging-comparison of optimized sequences. Radiology 2003;228:709-718   DOI   ScienceOn
22 Kim MJ, Kim JH, Choi JY, et al. Optimal TE for SPIOenhanced gradient-recalled echo MRI for the detection of focal hepatic lesions. AJR Am J Roentgenol 2006;187:W255- W266   DOI
23 Bellin MF, Zaim S, Auberton E, et al. Liver metastases: safety and Efficacy of detection with superparamagnetic iron oxide in MR imaging. Radiology 1994;193:657-663   DOI
24 de Bazelaire CM, Duhamel GD, Rofsky NM, Alsop DC. MR Imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0T : preliminary results. Radiology 2004;230:652-659   DOI   ScienceOn
25 Bottomley PA, Foster TH, Argersinger RE, Pfeifer LM. A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. Med Phys 1984;11:425-448   DOI   ScienceOn
26 Hahn PF, Stark DD, Weissleder R, Elizondo G, Saini S, Ferrucci JT. Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors. Radiology 1990;174:361-366   DOI
27 Reimer P, Tombach B. Hepatic MRI with SPIO: detection and characterization of focal liver lesions. Eur Radiol 1998;8:1198- 1204   DOI   ScienceOn
28 von Falkenhausen M, Meyer C, Lutterbey G, et al. Intraindividual comparison of image contrast in SPIO-enhanced liver MRI at 1.5T and 3.0T. Eur Radiol 2007;17:1256-1261   DOI   ScienceOn
29 Van Beers BE, Gallez B, Pringot J. Contrast-enhanced MR iaging of the liver. Radiology 1997;203:297-306