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http://dx.doi.org/10.7841/ksbbj.2016.31.3.178

Skin Volume Augmentation and Anti-wrinkle Effects of Tribulus terrestris Fruit Extract  

Kim, Mi Jin (Skin Science R&D Center, Saimdang Cosmetics Co., Ltd.)
Jung, Taek Kyu (Skin Science R&D Center, Saimdang Cosmetics Co., Ltd.)
Park, Hyun-Chul (Skin Science R&D Center, Saimdang Cosmetics Co., Ltd.)
Yoon, Kyung-Sup (Skin Science R&D Center, Saimdang Cosmetics Co., Ltd.)
Publication Information
KSBB Journal / v.31, no.3, 2016 , pp. 178-185 More about this Journal
Abstract
Aging of the face is mainly related to the features that are sagging or loss of elasticity of the skin by reducing the volume around the eyes or cheek. Intrinsic aging can be seen to cause thinner dermis, reduction of extracellular matrix and subcutaneous fat. This study was carried out to investigate the skin volume augmentation and anti-wrinkle effects of Tribulus terrestris fruit extract. Skin anti-aging effect of Tribulus terrestris fruit extract was evaluated by using lipid accumulation, expressin of type I procollagen and elastin in preadipocytes and human dermal fibroblasts. Tribulus terrestris fruit extract augmented preadipocytes differentiation about 56% at 100 µg/mL. The type I procollagen and elastin were increased about 35% and 25% by treatment 20% Tribulus terrestris fruit extract, respectively. The clinical study also showed that skin sagging, skin elasticity, and dermal density improved without adverse effect following 4 week application of cream containing 2% Tribulus terrestris fruit extract. We suggest that Tribulus terrestris fruit extract can have the good possibility as skin volume augmenting, skin elasticity and wrinkle improving agent.
Keywords
Anti-wrinkle; Elasticity; Skin volume; Subcutaneous fat; Tribulus terrestris fruit extract;
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1 Angelos, P. C., C. L. Stallworth, and T. D. Wang (2011) Forehead lifting: state of the art. Facial Plast. Surg. 27: 50-57.   DOI
2 Park, J. Y.,and J. H. Bae (2012) Understanding of the aging face. J. Rhinol. 19: 87-90.
3 Ohshima, H., S. Kinoshita, M. Oyobikawa, M. Futaqawa, H. Takiwaki, A. Ishiko, and H. Kanto (2013) Use of cutometer area parameters in evaluating age-related changes in the skin elasticity of the cheek. Skin Res. Technol. 19: e238-242.   DOI
4 Escoffier, C., J. de Rigal, A. Rochefort, R. Vasselet, J. L. Leveque, and P. G. Aqache (1989). Age-related mechanical properties of human skin: an in vivo study. J. Invest. Dermatol. 93: 353-357.   DOI
5 Mentz, H. A., A. Ruiz-Razura, C. K. Patronella, and G. Newall (2005) Facelift: measurement of superficial muscular aponeurotic system advancement with and without zygomaticus major muscle release. Aesthetic Plast. Surg. 29: 353-362.   DOI
6 You, Y. J. and H. S. Lee (1999) Effects of fructus Tribuli on the blood pressure in spontaneously hypertensive rats. The Journal of Traditional Korean Medicine 9: 192-199.
7 Kang, S. Y., J. H. Han, and K. Y. Kim (1998) Effect of fructus Tribuli extract on regional cerebral blood flow and pil arterial diameter. J. Herbol. 13: 187-200.
8 Lee, D. H., H. H. Yu, S. Y. Jung, H. D. Moon, S. M. Kim, B. H. Jeon, and Y. O. You (2007) Anticariogenic properties of the ethanol extract of Tribuli fructus against Streptococcus mutans. Korean J. Oriental Physiol. Pathol. 21: 1148-1153.
9 DeFatta, R. J. and E. F. 3rd Williams (2011) Midface lifting: current standards. Facial Plast Surg. 27: 77-85.   DOI
10 Zhang, J. D, Y. B. Cao, Z. Xu, H. H. Sun, M. M. An, L. Yan, H. S. Chen, P. H. Gao, Y. Wang, X. M. Jia, and Y. Y. Jiang (2005) In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. with potent activity against Fluconazole- resistant fungal. Biol. Pharm. Bull. 28: 2211-2215.   DOI
11 Fang, S., C. Hao, Z. Liu, F. Song, and S. Liu (1999) Application of electrospray ionization mass spectrometry combined with sequential tandem mass spectrometry techniques for the steroidal saponin mixture extracted from Tribulus terrestris. Planta Med. 65: 68-73.   DOI
12 Kostova, I., D. Dinchev, G. H. Rentsch, V. Dimitrov, and A. Ivanova (2002) Two new sulfated furostanol saponins from Tribulus terrestris. Z. Naturforsch 57: 33-38.
13 Li, J. X., Q. Shi, Q. B. Xiong, J. K. Prasain, Y. Tezuka, T. Hareyama, Z. T. Wang, K. Tanaka, T. Namba, and S. Kadota (1998) Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestirs, Indications of cytoprotective activity in murine hepatocyte culture. Planta Med. 64: 628-631.   DOI
14 Wu, T. S., L. S. Shi, and S. C. Kuo (1999) Alkaloids and other constituents from Tribulus terrestris. Phytochemistry 50: 1411-1415.   DOI
15 Hong, S. S, W. S. Jeong, J. G. Kwon, Y. H. Choi, E. K. Ahn, H. J. Ko, D. W. Seo, and J. S. Oh (2013) Phenolic amides from the fruits of Tribulus terrestris and their inhibitory effects on production of nitric oxide. Bull. Korean Chem. Soc. 34: 3105-3108.   DOI
16 Sedama. (2007) Cosmetic composition containing sarsasapogenin. JP 21545582.
17 Green, L. M., J. L. Reade, and C. F. Ware (1984) Rapid colorimetric assay for cell viability: application to the quantitation of cytotoxic and growth inhibitory lymphokines. J. Immunol. Methods 70: 257-268.   DOI
18 Huang, K. C. (1999) The pharmacology of chinese herbs. 2nd ed., pp. 165. CRC Press LLC, USA.
19 Lee, D. G., Y. K. Park, M. R. Kim, H. J. Jung, Y. B. Seu, K. S. Hahm, and E. R. Woo (2004) Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense. Biotechnol. Lett. 26: 1125-1130.   DOI
20 Li, W. J., X. L. Cheng, J. Liu, R. C. Lin, G. L. Wang, S. S. Du, and Z. L. Liu (2012) Phenolic compounds and antioxidant activities of Liriope muscari. Molecules 17: 1797-1808.   DOI
21 Song, Y. H., D. W. Kim, M. J. Curtis-Long, C. Park, M. Son, J. Y. Kim, H. J. Yuk, K. W. Lee, and K. H. Park (2016) Cinnamic acid amides from Tribulus terrestris displaying uncompetitive ${\alpha}$-glucosidase inhibition. Eur. J. Med. Chem. 114: 201-208.   DOI
22 Friedman, O. (2005) Changes associated with the aging face. Facial Plast. Surg. Clin. North. Am. 13: 371-380.   DOI
23 Lapiere, C. M. (1990) The ageing dermis: the main cause for the appearance of 'old' skin. Br. J. Dermatol. 35: 5-11.
24 Gilchrest, B. A. (1989) Skin aging and photoaging: an overview. J. Am. Acad. Dermatol. 21: 610-613.   DOI
25 Zoumalan, R. A. and W. F. Jr. Larrabee (2011) Anatomic considerations in the aging face. Facial Plast. Surg. 27: 16-22.   DOI
26 Wu, Y., Z. R. Wu, P. Chen, L. Yang, W. R. Deng, Y. Q. Wang, and H. Y. Li (2015) Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells. Bioorg. Med. Chem. Lett. 25: 1476-1478.   DOI