Cell Cycle Arrest of Extract from Artemisia annua Linné. Via Akt-mTOR Signaling Pathway in HCT116 Colon Cancer Cells |
Kim, Bo Min
(Department of Biological sciences and Biotechnology, College of Life Science and Nano Technology, Hannam University)
Kim, Guen Tae (Department of Biological sciences and Biotechnology, College of Life Science and Nano Technology, Hannam University) Lim, Eun Gyeong (Department of Biological sciences and Biotechnology, College of Life Science and Nano Technology, Hannam University) Kim, Eun Ji (Department of Biological sciences and Biotechnology, College of Life Science and Nano Technology, Hannam University) Kim, Sang Yong (Department of BIONGENE) Ha, Sung Ho (Department of Chemical Engineering, College of Life Science and Nano Technology, Hannam University) Kim, Young Min (Department of Biological sciences and Biotechnology, College of Life Science and Nano Technology, Hannam University) |
1 | Rebecca, S., M. Jiemin, Z. Zhaohui, and J. Ahmedin (2014) Cancer Statistics. Ca. Cancer J. Clin. 64: 9-29. DOI |
2 | Kim, W. S., R. A. Lee, D. Y. Hwang, Y. J. Hong, and S. I. Hong (2004) Histoculture drug response assay in colorectal cancer specimen. J. Korean Surg. Soc.66 : 109-115. |
3 | Andersen, C., L. Adamsen, T. Moellar, J. Midtaard, M. Quist, A. Tvet-eraas, and M. Rorth (2006) The effect of a multidmensional exercise pro-gramme on symptoms and side-effects in canner patients undergoing chemotherapy-The use of semi-structured diaries. Eur. J. Oncel. Nurs.10: 247-262. DOI |
4 | Ryu, J. H., S. J. Lee, M. J. Kim, J. H. Shin, S. K. Kang, K. M. Cho, and N. J. Sung (2011) Antioxidant and anticancer activities of Artemisia annua L. and determination of functional compounds. J. Korean Soc. Food Sci. Nutr. 40: 509-516. DOI |
5 | Kim, R. J., M. J. Kang, C. R. Hwang, W. J. Jung, and J. H. Shin (2012) Antioxidant and cancer cell growth inhibition activity of five different varieties of Artemisia Cultivars in Korea. J. Life Sci. 22: 844-851. DOI ScienceOn |
6 | Jin, S., S. G. Yun, Y. N. Oh, J. Y. Lee, H. J. Park, K. S. Jin, H. J. Kwon, and B. W. Kim (2013) Induction of G2/M arrest and apoptosis by the methanol extract of typha orientalis in human colon Adenocarcinoma HT29 cells. Kormb. 41: 425-432. |
7 | Kim, D. W., K. S. Lee, M. K. Kim, Y. H. Cho, and C. H. Lee (2001) Inhibitory mechanisms of cell cycle regulation induced by indole-3-carbinol in hepatocellular carcinoma HepG2 cells. Kor. J. Appl. Microbiol. Biotechnol. 29: 181-185. |
8 | Katrien, V., D. R. Van Bockstaele, and Z. N. Berneman (2004) The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36: 131-149. |
9 | Carnero, A. (2010) The PKB/AKT pathway in cancer. Curr. Pharm. Des. 16: 34-44. DOI |
10 | Lee, S. H., I. S. Kim, S. Y. Park, O. J. Park, and Y. M. Kim (2011) Quercetin induces apoptosis via regulation of mTOR-VASP signaling pathway in HT-29 colon cancer cells. Cancer Prev. Res. 16: 340-347. |
11 | Lee, Y. K., S. Y. Park, Y. M. Kim, D. C. Kim, W. S. Lee, Y. J. Surh, and O. J. Park (2010) Suppression of mTOR via Akt-dependent and -independent mechanisms in seleniumtreated colon cancer cells: Involvement of AMPKa1. Carcinogenesis. 31: 1092-1099. DOI |
12 | Agarwal, M. L., A. Agarwal, W. R. Taylor, and G. R. Stark (1995) p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. PNAS 92: 8493-8497. DOI |
13 | Hongyan, Z., N. Linghu, and G. Carl (2005) Cdk2-dependent inhibition of p21 stability via a C-terminal cyclin-binding motif. JBC 280: 29282-29288. DOI |
14 | Vidushi, S. N., B. Theeshan, W. T. Ethan, S. J. Ling, and A. OkezieI (2010) Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention. Sci. Direct. 278: 229-241. |
15 | Iwao, M., Z. Fang, H. Tomomi, O. Junichi, K. Kiyoshi, S. Kazuo, and J. David (2010) Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest. Oncol. Rep. 24: 1677-1681. |
16 | Wei, D., Y. Yi, H. Zhang, J. Bergholz, J. Wu, H. Ying, Y. Zhang, and J. X. Zhi-Xiong (2013) Rapamycin inhibits -1-eediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy. PLoS ONE 8: e63179. DOI |
17 | Andrei, L. G. and A. Tyner (2002) The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Molec. Cancer Therapeutics 1: 639-649. |
18 | Park, S. Y., S. H. Lee, O. J. Park, and Y. M. Kim (2011) Apoptotic effects of curcumin and EGCG via Akt-p53 signaling pathway in HCT116 colon cancer cells. JLS 21: 89-95. DOI |
19 | Donjerkovic, D. and D. W. Scott (2000) Regulation of the G1 phase of the mammalian cell cycle. Cell Res. 10: 1-16. DOI |
20 | Lindsy, D. M. and D. B. Donner (2002) The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Sci. Direct. 27: 462-467. |