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http://dx.doi.org/10.7841/ksbbj.2014.29.1.50

Study on the Anti-inflammatory Effect and Mechanism of Prunus mume Extract Regarding NF-κB  

Seo, Won-Sang (Department of Microbial Engineering, Konkuk university)
Oh, Han-Na (Charmzone R&D Center, Charmzone Cosmetic, Ltd.)
Park, Woo-Jung (Charmzone R&D Center, Charmzone Cosmetic, Ltd.)
Um, Sang-Young (Charmzone R&D Center, Charmzone Cosmetic, Ltd.)
Lee, Dae-Woo (R&D Center, DERMALAB Co. Ltd.)
Kang, Sang-Mo (Department of Microbial Engineering, Konkuk university)
Publication Information
KSBB Journal / v.29, no.1, 2014 , pp. 50-57 More about this Journal
Abstract
NF-${\kappa}B$ is a transcriptional factor which is involved in many biological processes including immunity, inflammation, and cell survival. Many investigators studied on the mechanism involved in activation of NF-${\kappa}B$ signalling pathway via ubiquitination and degradation of $I{\kappa}B$ regarding skin disease. Some specific molecules including Akt, MEK, p38 MAP Kinase, Stat3, et al. represent convergence points and key regulatory proteins in signaling pathways controlling cellular events such as growth and differentiation, energy homeostasis, and the response to stress and inflammation. Ultraviolet (UV) irradiation has many adverse effects on skin, including inflammation, alteration in the extracellular matrix, cellular senescence, apoptosis and skin cancer. Prunus mume, a naturally derived plant extract, has beneficial biological activities as blood fluidity improvement, anti-fatigue action, antioxidative and free radical scavenging activities, inhibiting the motility of Helicobacter pyolri. Previous reports on various beneficial function prompted us to investigate UVB-induced or other immunostimulated biological marker regarding P. mume extract. P. mume extract suppresses UVB-induced cyclooxygenase-2 (COX-2) expression in mouse skin epidermal JB6 P+ cells. The activation of activator protein-1 and nuclear factor-${\kappa}B$ induced by UVB was dose-dependently inhibited by P. mume extract treatment. This results suggest that P. mume extracts might be used as a potential agents for protection of inflammation or UVB induced skin damage.
Keywords
Prunus mume; Nuclear factor-${\kappa}B$; Cyclooxygenase-2; Activator protein-1;
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1 Beissert, S. and R. Granstein (1996) UV-induced cutaneous photobiology. Crit. Rev. Biochem. Mol. Biol. 31: 381-404.   DOI   ScienceOn
2 Sen, R. and D. Baltimore (1988) Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism. Cell 47: 921-928.
3 Lin, A. and M. Karin (2003) NF-kB in cancer: a marked target. Semin. Cancer Biol. 13: 107-114.
4 Kim, D. and J. Chung (2002) Akt: versatile mediator of cell survival and beyond. J. Biochem. Mol. Biol. 35: 106-115.   과학기술학회마을   DOI
5 Alessi, D. R., Y. Saito, D. G. Campbell, P. Cohen, G. Sithanandam, and U. Rapp (1994) Ashworth A, Marshall CJ, Cowley S, Identification of the sites in MAP kinase kinase-1 phosphorylated by p74 raf-1. EMBO J. 13:1610-1619.
6 O'Shea, J. J., M. Gadina, and R. D. Schreiber (2002) Cell. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. 109: S121-S131.   DOI   ScienceOn
7 Raingeaud, J., S. Gupta, J. S. Rogers, M. Dickens, J. Han, R. J. Ulevitch, and R. J. Davis (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270: 7420-7426.   DOI   ScienceOn
8 Zarubin, T. and J. Han (2005) Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15: 11-18.   DOI
9 Roux, P. P. and J. Blenis (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68: 320-344.   DOI   ScienceOn
10 Melnikova, V. O. and H. N. Ananthaswamy (2005) Cellular and molecular events leading to the development of skin cancer. Mutation Research 571: 91-106.   DOI   ScienceOn
11 Matsumura Y. and H. N. Ananthaswamy (2004) Toxic effects of ultraviolet radiation on the skin. Toxicol Applied Pharmacol 195: 298-308.   DOI   ScienceOn
12 Enomoto, S., K. Yanaoka, H. Utsunomiya, T. Niwa, K. Inada, H. Deguchi, K. Ueda, C. Mukoubayashi, I. Inoue, T. Maekita, K. Nakazawa, M. Iguchi, K. Arii, H. Tamai, N. Yoshimura, M. Fujishiro, M. Oka, and M. Ichinose (2010) Inhibitory effects of Japanese apricot (Prunus mume Siebold et Zucc.; Ume) on Helicobacter pylori-related chronic gastritis. Eur. J. Clin. Nutr. 64: 714-719.   DOI   ScienceOn
13 Bode, A. M. and Z. Dong (2003) Mitogen-activated protein kinase activation in UV-induced signal transduction. Sci STKE RE2.
14 Smith, W. L., D. L. DeWitt, and R. M. Garavito (2002) Cyclooxygenases: structural, cellular, and molecular biology. Ann. Rev. Biochem. 69: 145-182.
15 Chuda, Y., H. Ono, M. Ohnishi-Kameyama, K. Matsumoto, T. Nagata, and Y. Kikuchi (1999) Mumefural, citric acid derivative improving blood fluidity from fruit-juice concentrate of Japanese apricot (Prunus mume Sieb. et Zucc). J. Agric. Food Chem. 47: 828-831.   DOI   ScienceOn
16 Kim, B. J., J. H. Kim, H. P. Kim, and M. Y. Heo (1997) Biological screening of 100 plant extracts for cosmetic use (II): anti-oxidative activity and free radical scavenging activity. Int. J. Cosmet. Sci. 19: 299-307.   DOI   ScienceOn
17 Miyazawa, M., H. Utsunomiya, K. Inada, T. Yamada, Y. Okuno, H. Tanaka, and M. Tatematsu (2006) Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese apricot. Biol. Pharm. Bull. 29: 172-173.   DOI
18 Nakajima, S., K. Fujita, Y. Inoue, M. Nishio, and Y. Seto (2006) Effect of the folk remedy, Bainiku-ekisu, a concentrate of Prunus mume juice, on Helicobacter pylori infection in humans. Helicobacter. 11: 589-591.   DOI   ScienceOn
19 Yu, H., D. Pardoll, and R. Jove (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 9: 798-809.   DOI   ScienceOn
20 Tsuji, R., H. Koizumi, and D. Fujiwara (2011) Effects of a plum (Prunus mume Siebold and Zucc.) ethanol extract on the immune system in vivo and in vitro. Biosci. Biotechnol. Biochem. 75: 2011-2013.   DOI   ScienceOn
21 Gao, H. and P. A. Ward (2007) STAT3 and suppressor of cytokine signaling 3: potential targets in lung inflammatory responses. Expert Opin. Ther. Targets 11: 869-880.   DOI   ScienceOn
22 Andrs, R. M., M. C. Montesinos, P. Navaln, M. Pay, and M. C. Terencio (2013) NF-${\kappa}B$ and STAT3 Inhibition as a Therapeutic Strategy in Psoriasis: In Vitro and In Vivo Effects of BTH. J. Invest. Dermatol. doi: 10.1038/jid.2013.182.   DOI
23 Setlow, R. B. (1974) The wavelengths in sunlight effective in producing skin cancer: a theoretical analysis. Proc. Natl. Acad. Sci. USA 71: 3363-3366.   DOI   ScienceOn
24 Alessi, D. R., M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B. A. Hemmings (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15: 6541-6551.
25 Sarbassov, D. D., D. A. Guertin, S. M. Ali, and D. M. Sabatini (2005) Phosphorylation and regulation of Akt/PKB by the rictormTOR complex. Science 307: 1098-1101.   DOI
26 Ley, R. D. (1974) Photoreactivation in humans. Proc. Natl. Acad. Sci. USA 90: 4337.
27 Hess, J., P. Angel, and M. Schorpp-Kistner (2004) AP-1 subunits: quarrel and harmony among siblings. J. Cell. Sci. 117: 5965-5973.   DOI   ScienceOn
28 Lee, J. L., H. Mukhtar, D. R. Bickers, L. Kopelovich, and M. Athar (2003) Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol. Applied Pharmacol. 192: 294-306.   DOI   ScienceOn
29 Ameyar, M., M. Wisniewska, and J. B. Weitzman (2003) A role for AP-1 in apoptosis: the case for and against. Biochimie 85: 747-752.   DOI   ScienceOn
30 Fischer, S. M., H. H. Lo, and G. B. Gordon (1999) Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. Mol. Carcinog. 25: 231-240.   DOI
31 Karin, M. (1998) Mitogen-activated protein kinase cascades as regulators of stress responses. Ann. NY Acad. Sci. 851: 139-146.   DOI
32 Jacinto, E., V. Facchinetti, D. Liu, N. Soto, S. Wei, S. Y. Jung, Q. Huang, J. Qin, and B. Su (2006) SIN1/MIP1 maintains rictormTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127: 125-137.   DOI   ScienceOn
33 DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. A. Karin (1997) cytokine-responsive IkB kinase that activates the transcriptional factor NF-kB. Nature 388: 548-554.   DOI   ScienceOn
34 Chen, W., Q. Tang, M. S. Gonzales, and G. T. Bowden (2001) Role of p38 MAP kinases and ERKin mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene. 20: 3921-3926.   DOI   ScienceOn
35 Ding, M., R. Feng, and S. Y. Wang (2006) Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J. Biol. Chem. 281: 17359-17368.   DOI   ScienceOn
36 Matsumuram Y. and H. Ananthaswamy (2002) Short-term and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicine. Expert Rev. Mol. Med. 26: 1-22.