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http://dx.doi.org/10.7841/ksbbj.2013.28.3.208

Effect of Pore Size of Mesoporous Spherical Silica for the Purification of Paclitaxel from Plant Cell Cultures  

Oh, Hyeon-Jeong (Department of Chemical Engineering, Kongju National University)
Jung, Kyeong Youl (Department of Chemical Engineering, Kongju National University)
Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
Publication Information
KSBB Journal / v.28, no.3, 2013 , pp. 208-212 More about this Journal
Abstract
Four types of mesoporous spherical silica adsorbents with different physical properties were prepared by spray pyrolysis and were used for the purification of the anticancer agent paclitaxel from plant cell cultures. Pore size had a greater effect on the removal of plant-derived impurities during the pre-purification of paclitaxel compared with surface area and pore volume. An appropriate pore diameter (~9.07 nm) was required to achieve the highest purity (~46.1%) and yield (~82.3%) of paclitaxel. These results were confirmed by HPLC analysis of the absorbent after treatment and Thermogravimetric analysis of the organic substances bonded to the adsorbent.
Keywords
Paclitaxel; Purification; Mesoporous silica; Adsorbent; Pore size;
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Times Cited By KSCI : 2  (Citation Analysis)
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