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http://dx.doi.org/10.7841/ksbbj.2013.28.2.74

Antifungal Activities of Hemistepsin A and B Isolated from Hemistepita lyrata Bunge against Dandruff-causing Microbe Malassezia obutusa  

Lee, Jong Rok (Department of Pharmaceutical Engineering, Daegu Haany University)
Jung, Dae Hwa (Research Center for Biomedical Resources of Oriental Medicine, Daegu Haany University)
Park, Moon Ki (Department of Pharmaceutical Engineering, Daegu Haany University)
Publication Information
KSBB Journal / v.28, no.2, 2013 , pp. 74-79 More about this Journal
Abstract
There are a large number of bioactive sesquiterpene lactones from compositae plants including Hemistepita lyrata Bunge. In the present study, we purified two sesquiterpene lactones, Hemistepsin A and B, from H. lyrata and evaluated their antimicrobial activities against Malassezia obutusa. Chromatographic separation was used for the preparation of Hemistepsin A and B, and the identity of these compounds was confirmed by NMR. Strong inhibition of growth of M. obutusa was obtained with all doses of Hemistepsin A tested. Moreover, antifungal activity of Hemistepsin A occurred in a dose-dependent manner. Hemistepsin B also showed potent antifungal activity at the dose of $800{\mu}m/disc$. From these results, it was suggested that Hemistepsin A and B be beneficial for the preparation of the useful agent for treating scalp diseases occurred by dandruff-causing Malassezia species.
Keywords
Hemistepsin A; Hemistepsin B; Antifungal Activity; Dandruff; Hemistepita lyrata;
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