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http://dx.doi.org/10.7841/ksbbj.2013.28.1.36

Evaluation of Antioxidant and Anti-Inflammatory Activities of Ascidian Tunic Carotenoids As a Source of Color Cosmetics  

Ticar, Bernadeth (Department of Seafood Science and Technology/The Institue of Marine Industry, Gyeongsang National University)
Rohmah, Zuliyati (Department of Seafood Science and Technology/The Institue of Marine Industry, Gyeongsang National University)
Bat-Erdene, Munkhjagal (Department of Seafood Science and Technology/The Institue of Marine Industry, Gyeongsang National University)
Park, Si-Hyang (Sunmarine Biotech Co.)
Choi, Byeong-Dae (Department of Seafood Science and Technology/The Institue of Marine Industry, Gyeongsang National University)
Publication Information
KSBB Journal / v.28, no.1, 2013 , pp. 36-41 More about this Journal
Abstract
Carotenoids are fat-soluble red-orange colored pigments found in plants and seafood-derived products, including algae, seaweeds, and fish muscle. In this study, we have demonstrated the molecular mechanism underlying the antioxidants and anti-inflammatory properties of ascidian tunic carotenoids using mouse macrophage cell line (RAW 264.7). Cell viability was not affected by treatment of carotenoids < 10 ${\mu}g/mL$. This treatment also showed negative inhibition on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) and cyclooxygenase-2 (COX-2). The DPPH radical scavenging activity of carotenoids was 47.2% at 100 mg/mL. It also has a potential reducing power (1.025) comparable with ascorbic acid (1.584). The ascidian tunic carotenoids would make a candidate for the commercially interesting biologically active cosmetic pigments.
Keywords
Ascidian tunic carotenoids; DPPH radical; color cosmetics; NO; COX-2;
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Times Cited By KSCI : 11  (Citation Analysis)
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