Browse > Article
http://dx.doi.org/10.7841/ksbbj.2012.27.6.325

Anti-inflammatory Activity of the Water Extract of Sargassum fulvellum  

Jeong, Da-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukoung National University)
Kim, Koth-Bong-Woo-Ri (Institute of Fisheries Sciences/Pukyong National University)
Kang, Bo-Kyeong (Department of Food Science & Technology/Institute of Food Science, Pukoung National University)
Jung, Seul-A (Department of Food Science & Technology/Institute of Food Science, Pukoung National University)
Kim, Hyun-Jee (Department of Food Science & Technology/Institute of Food Science, Pukoung National University)
Jeong, Hee-Ye (Department of Food Science & Technology/Institute of Food Science, Pukoung National University)
Bark, Si-Woo (Department of Food Science & Technology/Institute of Food Science, Pukoung National University)
Ahn, Dong-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukoung National University)
Publication Information
KSBB Journal / v.27, no.6, 2012 , pp. 325-329 More about this Journal
Abstract
The anti-inflammatory effects of Sargassum fulvellum water extracts (SFWE) were investigated using lipopolysaccharide (LPS)-induced inflammatory response in this study. To examine the potential anti-inflammatory properties of SFWE, the NO, TNF-${\alpha}$, IL-6, IL-$1{\beta}$, and cell proliferation were measured. It was confirmed that the NO and TNF-${\alpha}$ secretion were significantly suppressed when SFWE was added to LPS-stimulated RAW 264.7 cells. Moreover, the expression of IL-6 and IL-$1{\beta}$ cytokines was suppressed by SFWE in a dose-dependent manner. Especially, IL-6 inhibition activities were over 50% at 1% of SFWE. The cytotoxicity of SFWE and the proliferation of macrophages was measured by MTT assay. As a result, there was no cytotoxicity in the macrophage proliferation treated with SFWE compared to the control. In conclusion, these results suggested that the SFWE may have significant effects on inflammatory factors and can be a potential anti-inflammatory therapeutic materials.
Keywords
Sargarssum fulvellum; anti-inflammatory;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
연도 인용수 순위
1 Heo, Y. and H. A. Kim (2008) Correlation between skin prick test and enzyme-linked immunoabsorbent assay using serum for identification of subjects positive to major respiratory allergens. J. Env. Hlth. Sci. 24: 369-373.
2 Park, G. H., J. Y. Lee, D. H. Kim, Y. J. Cho, and B. I. An (2011) Anti-oxidant and antiinflammatory effects of Rosa multiflora root. J. Life Sci. 21: 1120-1126.   과학기술학회마을   DOI
3 Jew, S. S., O. N. Bae, and J. H. Chung (2003) Anti-inflammatory effects of asiaticoside on inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cell line. J. Toxicol. Pub. Health 19: 33-37.   과학기술학회마을
4 Ljung, T., S. Lundberg, M. Varsanyi, C. Johansson, P. T. Schmidt, M. Herulf, J. O. Jundberg, and P. M. Hellstrom (2006) Rectal nitric oxide as biomaker in the treatmen of inflammatory bowel disease: responders versus non-responders. World J. Gastroenterol. 12: 3386-3392.   DOI
5 Higuchi, M., N. Hisgahi, H. Taki, and T. Osawa (1990) Cytolytic mechanism of activetaed macrophages. Tumor necrosis factor and L-arginine-dependent mechanism act synergistically as the major cytolytic mechanism of activated macrophages. J. Immunol. 144: 1425-1431.
6 Guha, M. and N. Mackman (2001) LPS induction of gene expression in human monocyte. Cell Signal. 13: 85-94.   DOI   ScienceOn
7 Gracie, J. A., R. J. Forsey, W. L. Chan, A. Cilmour, B. P. Leung, M. R. Greer, K. Kennedy, R. Carter, X. Q. Wei, D. Xu, M. Field, A. Foulis, F. Y. Liew, and I. B. Mclnnes (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J. Clin. Invest. 13: 85-94.
8 Chen, Y. Y., J. F. Liu, C. M. Chen, P. Y. Chao, and T. J. Chang (2003) A study of antioxidative and antimutagenic effects of Houttuynia cordata thunb using an oxidized frying oil-fed model. J. Nutr. Sci. Vitaminol. 49: 327-333.   DOI
9 Lee, K. H., J. O. Nam, and W. H. Yoon (2007) Effect of proteinbound polysaccharide isolated from Acanthopananx senticosus in reducing the toxic effect of cisplatin. Korean J. Pharmacogn. 38: 1-17.
10 Kawashima, S., M. Hayashi, R. Takii, H. Kimura, H. L. Zhang, A. Nagatsu, J. Sakakibara, K. Murata, Y. Oomoto, and K. Onozaki (1998) Serotonin derivative, N-($\rho$-coumaroyl) serotonin, inhibits the production of TNF-$\alpha$, IL-$1 \alpha$, IL-$1 \beta$ and IL-6 by endotoxinstimulated human blood monocytes. J. Interf. Cytok, Res. 18: 423-428.   DOI   ScienceOn
11 Yun, Y. G., G. M, Kim, S. J. Lee, S. H. Ryu, and S. I. Jang (2007) Inhibitory effect of aqueous extract from Lonicera japonica flower on LPS-induced inflammatory mediators in RAW 264.7 macrophages. Korean J. Herbology 22: 117-125.   과학기술학회마을
12 Lee, H. N., D. Y. Lim, S. S. Lim, J. D. Kim, and J. H. Y. Park (2011) Anti-inflammatory effect of ethanol extract from Eupatorium japonicum. Korean J. Food Sci. Technol. 43: 65-71.   과학기술학회마을   DOI
13 Yoon, W. J., J. A. Lee, K. N. Kim, J. Y. Kim, and S. Y. Park (2007) In vitro anti-inflammatory activity of the Artemisia fukudo extract in murine macrophage RAW 264.7 cells. Korean J. Food Sci. Technol. 39: 464-469.
14 Imm, J. Y. and S. J. Kim (2010) Anti-cancer and anti-inflammatory effects of mung bean and soybean extract. Korean J. Food Sci. Technol. 42: 755-761.
15 Weisz, A., L. Cicatiello, and H. Esumi (1996) Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-gamma, bacterial lipopolysaccharide and NGmonomethyl- L-arginine. Biochem. J. 316: 209-215.   DOI
16 Bae, S. J. (2004) Anticarcinogenic effects of Sargassum fulvellum fraction on several human cancer cell lines in vitro. J. Korean Soc. Food Sci. Nutr. 33: 480-486.   DOI
17 Lee, H. S., H. S. Jung, and H. S. Kuen (2000) Preparation of antibacterial agent from seaweed extract and its antibacterial effect. J. Korean Fish Soc. 33: 32-37.   과학기술학회마을
18 Lee, H. B., B. W. Choi, J. H. Chun, and B. S. Yu (1996) Extraction of water soluble antioxidants from seaweeds. J. Korean Ind. Eng. Chem. 7: 1069-1077.   과학기술학회마을
19 Jirik, F. R., T. J. Podor, T. Hirano, T. Kishimoto, D. J. Loskuroff, D. A. Carson, and M. Lotz (1989) Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J. Immunol. 142: 144-147.
20 Brian, T. (2002) The effect of fetal acidemia on fetal-placental vascular tone and production of inflammatory cytokines interleukin-6 and tumor necrosis factor-$\alpha$. Am. J. Obstet. Gynenol. 187: 894-897.   DOI   ScienceOn
21 Charles, N. (2003) Expression of cyclooxygenase-2 in cervical, endometrial and ovarian malignancies. Am. J. Obstet. Gynenol. 188: 1174-1176.   DOI
22 Sung, J. H., D. H. Choi, D. H. Kim, B. G. Chun, and S. H. Choi (2004) White ginseng saponin upregulated the production of TNF-$\alpha$, IL-$1 \beta$, and NO in primary cultures of mixed glial cells. J. Ginseng Res. 28: 120-126.   DOI
23 Jin, D. Q., C. S. Lim, J. Y. Sung, H. G. Choi, I. H. Ha, and J. S. Han (2006) Ulva conglabata, a marine alfa, has neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells. Neurosci. Lett. 402: 154-158.   DOI   ScienceOn
24 Yoon, W. J., Y. M. Ham, S. S. Kim, B. S. Yoo, J. Y. Moon, J. S. Baik, N. H. See, and C. G. Hyun (2009) Suppression of proinflammatory cytokines iNOS and COX-2 expression by brown algae Sargassum micracanthumin RAW 264.7 macrophages. Eurasia. J. Biosix. 3: 130-143.