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http://dx.doi.org/10.7841/ksbbj.2012.27.4.237

Preparation of Zein Microparticles Using Supercritical Carbon Dioxide  

Ryu, Jong-Hoon (Department of Chemical Engineering, The University of Suwon)
Lim, Gio-Bin (Department of Chemical Engineering, The University of Suwon)
Publication Information
KSBB Journal / v.27, no.4, 2012 , pp. 237-242 More about this Journal
Abstract
In this study, zein microparticles and drug-loaded zein microparticles were prepared using supercritical ASES technique. The effects of operating parameters on particle size and morphology were investigated. ASES-processed zein microparticles consisted of agglomerates of very fine unit particles. As temperature increased, the size of unit particles increased and their morphology became more spherical. The addition of water to the solvents for zein resulted in the formation of more spherical microparticles. The release characteristics of drug-loaded zein microparticles were also studied.
Keywords
supercritical carbon dioxide; zein; fine particles; antisolvent; leuprolide acetate;
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