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http://dx.doi.org/10.7841/ksbbj.2011.26.6.569

Optimization of Reduction of 3-chloro-4-fluoropropiophenone by Whole Cells of Saccharomyces cerevisiae  

Lee, Hae-Ryong (School of Chemical Engineering, University of Ulsan)
Jeong, Min (School of Chemical Engineering, University of Ulsan)
Yoo, Ik-Keun (School of Chemical Engineering, University of Ulsan)
Hong, Soon-Ho (School of Chemical Engineering, University of Ulsan)
Publication Information
KSBB Journal / v.26, no.6, 2011 , pp. 569-571 More about this Journal
Abstract
Reduction of 3-chloro-4-fluoropropiophenone by Saccharomyces cerevisiae as a whole cell biocatalyst was optimized. Effects of glucose, S. cerevisiae and 3-chloro-4-fluoropropiophenone concentrations on conversion of reduction reaction was investigated. Optimum concentrations of glucose, S. cerevisiae and 3-chloro-4-fluoropropiophenone were 100, 40 and 20 g/L, respectively. At optimum condition, 100% of conversion was achieved in 12 hours of reaction.
Keywords
3-Chloro-4-fluoropropiophenone; Saccharomyces cerevisiae; Reduction; Biotransformation;
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1 Katzman, M. A. (2009) Current considerations in the treatment of generalized anxiety disorder. Adis International LTD, New Zealand. CNS Drugs 23: 103-120.   DOI   ScienceOn
2 Glieder, A., R. Weis, W.Skranc, P. Poechlauer, I. Dreveny, S. Majer, M. Wubbolts, H. Schwab, and K. Gruber (2003) Comprehensive step-by-step engineering of an (R)-hydroxynitrile lyase for large-scale asymmetric synthesis. Angew. Chem. Int. Ed. 42: 4815-4818.   DOI   ScienceOn
3 Sun, Y., X. Wan, J. Wang, Q. Meng, H. Zhang, L. Jiang, and Z. Zhang (2005) Ru-catalyzed asymmetric hydrogenation of ${\alpha}$-Ketoesters with CeCl3․7H2O as additive. Org. Lett. 7: 5425-5427.   DOI   ScienceOn
4 Uhm, K ., S. Lee, H . Kim, H . Kang, and Y. Lee (2007) Enantioselective resolution of methyl 2-chloromandelate by candida antarctica lipase A in a solvent-free transesterification reaction. J. Mol. Catal. B. Enzym. 45: 34-38.   DOI   ScienceOn
5 de Souza Pereira, R. (1998) The use of baker's yeast in the generation of asymmetric centers to produce chiral drugs and other compounds. Crit. Rev. Biotechnol. 18: 25-83.   DOI   ScienceOn
6 van Langen, L. M., R. P. Selassa, F. van Rantwijk, and R. A. Sheldon (2005) Cross-linked aggregates of (R)-oxynitrilase: a stable, recyclable biocatalyst for enantioselective hydrocyanation. Org. Lett. 7: 327-329.   DOI   ScienceOn
7 Johanson, T., M. Carlquist, C. Olsson, A. Rudolf, T. Frejd, and M. F. Gorwa-Grauslund (2008) Reaction and strain engineering for improved stereo-selective whole-cell reduction of a bicyclic diketone. Appl. Microbiol. Biotechnol. 77: 1111-1118.   DOI   ScienceOn
8 Katz, M., I. Sarvary, T. Frejd, B. Hahn-Hagerdal, and M. F. Gorwa-Grauslund (2002) An improved stereoselective reduction of a bicyclic diketone by Saccharomyces cerevisiae combining process optimization and strain engineering. Appl. Microbiol. Biotechnol. 59: 641-648.   DOI   ScienceOn
9 Li, G., K. Huang, Y. Jiang, and P. Ding (2007) Production of (R)-mandelic acid by immobilized cells of Saccharomyces cerevisiae on chitosan carrier. Process Biochem. 42: 1465-1469.   DOI   ScienceOn