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Preparation of Thiol-chitosan Coated EPA-containing Liposome and Immune Response in Mouse Model of Atopic Dermatitis  

Jung, Hyo-Yun (Interdisciplinary Program of Perfume and Cosmetics Graduate School, Chonnam National University)
Kim, Jin (Department of Advanced Chemicals & Engineering Graduate School, Chonnam National University)
Lee, Yong-Wook (Chemport Inc.)
Lee, Ki-Young (Interdisciplinary Program of Perfume and Cosmetics Graduate School, Chonnam National University)
Publication Information
KSBB Journal / v.25, no.1, 2010 , pp. 97-102 More about this Journal
Abstract
The enhancement of immunity for atopic dermatitis with application of eicosapentaenoic acid (EPA)-loaded liposome was evaluated on NC/Nga mice. The EPA-loaded liposome was coated with thiol-chitosan. The liposomes were characterized with transmission electron microscopy (TEM), surface zeta potential & particle size analyzer (Zeta-PSA) and differential scanning calorimetry (DSC). The loading efficiency of EPA in the liposome was about 4.7%. The particle size of the EPA-Ioaded liposome was about 230 nm. The values of Immunoglobulin E (IgE), interleukin-4 (IL-4), and tumor necrosis factor-$\alpha$ (TNF-$\alpha$) were reduced significantly with application of the EPA-loaded liposome. The interferon-$\gamma$ (IFN-$\gamma$) value was increased with the application effect. It is concluded that EPA loaded liposome have immunity advancing effects in mouse model of atopic dermatitis.
Keywords
EPA; Atopic dermatitis; Immunity; IgE; IL-4; TNF-$\alpha$; IFN-$\gamma$;
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Times Cited By KSCI : 1  (Citation Analysis)
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