Browse > Article

Melanin Inhibitory Effect and Anti-inflammatory Effects of Dietyota coriacea Extracts Derived from Adjacent Sea of the Jeju Island  

Kang, Min-Chul (Jeju Bio-Industry Development Center, Jeju Hi-Tech Industry Development Institute)
Lee, Ju-Yeop (Jeju Bio-Industry Development Center, Jeju Hi-Tech Industry Development Institute)
Ko, Ryeo-Kyeoung (Jeju Bio-Industry Development Center, Jeju Hi-Tech Industry Development Institute)
Kim, Haeng-Bum (Jeju Bio-Industry Development Center, Jeju Hi-Tech Industry Development Institute)
Hong, Seung-Ho (Department of Science Education, Teachers College, Cheju National University)
Kim, Gi-Ok (Jeju Bio-Industry Development Center, Jeju Hi-Tech Industry Development Institute)
Publication Information
KSBB Journal / v.23, no.4, 2008 , pp. 311-316 More about this Journal
Abstract
We investigated several biological activities using the ethanol extract and its fractions from Dictyota coriacea to evaluate the usefulness of its extract as a functional biomaterial. The ethanol extract and n-hexane and ethyl acetate fractions showed dependently inhibitory effect on tyrosinase activity and melanin content in B16F10 cells. The ethanol extract and its fractions showed inhibitory effect on Tyrosinase and TRP-1 gene transcription but didn't showed inhibitory effect on TRP-2 gene transcription. Also, the n-hexane and ethyl acetate fractions dose-dependently inhibited the NO production in a RAW 264.7 cells. These results suggest that extract of Dictyota coriacea could be used as functional biomaterial in developing a skin whitening agent having the anti-inflammatory activity.
Keywords
Dictyota coriacea; tyrosinase activity; melanin content; anti-inflammatory activity;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Chen, J. S., C. Wei, and M. R. Marshall (1991), Inhibition mechannism of Koji acid on polyphenol oxidase, J. Agric. Food Chem. 39, 1897-1901   DOI
2 Iozumi, K., G. E. Hoganson, R. Pemella, M. A. Everett, and B. B. Fuller (1993), Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes, J. Invest. Dermatol. 100, 806-811   DOI   ScienceOn
3 Jimenez-Cervantes, C., F. Solano, T. Kobayashi, K. Urabe, V. J. Hearing, J. Lozano, and C. Garcia-Borron (1994), Anew enzymatic function in the melanogenic pathway, J. Biol. Chem. 269, 17993-18001
4 Bennett, A., M. T. Del, I. F. Stamford, and T. Zebro (1977), Prostaglandins from tumers of human large bowel, Br. J. Surg. 35, 882-884
5 Romero-Graillet, C., E. Aberdam, N. Biagoli, W. Massabni, J. P. Ortonne, and R. Ballotti (1996), Ultraviolet B radiation acts through the nitric oxide and cGMP signal transduction pathway to stimulate melanogenesis in human melanocytes, J. Biol. Chem. 271(45), 28052-28056   DOI   ScienceOn
6 Weisz, A., L. Cicatielio, and H. Esumi (1996), Regulation of the mouse inducible-type nitric oxide sythase gene promoter by inferferongamma Bacterial lipopolysaccharide and NG-monomethyl-L-arginine, Biochem. J. 316, 209-215   DOI
7 Lee, B. G., S. H. Kim, O. P. Zee, K. R. Lee, K. Y. Lee, and H. W. Lee (2000), Suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by two-carboline alkaloids extracted from Melia azedarach, Eur J Pharmacol. 406, 301-309   DOI   ScienceOn
8 Nathan, C. (1992), Nitric oxide as a secretory product of mammalian cells, FASEB J. 6, 3051-3064   DOI
9 Urabe, K., P. Aroca, K. Tsukamoto, D. Mascagna, A. Paulumbo, G. Prota, and V. J. Hearing (1994), The inherent cytotoxicty of melanin precursors, Biochim. Biophys. Acta. 1221, 272-278   DOI   ScienceOn
10 Cabanes, J., S. Chazara, and C. F. Garcia (1994), Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase, J. Pharm. Pharmacol. 46, 982-985   DOI   ScienceOn
11 Kawamata, H., H. Ochiai, N. Mantani, and K. Terasawa (2000), Enhanced Expression of Inducible Nitric oxide Synthase by Junen-taiho-to in LPS-activated RAW 264.7 cells, a murine macrophage cell line, Am. J. Chin. Med. 28, 217-226   DOI
12 Romero-Graillet, C., E. Aberdam, M. Clement, J. P. Ortonne, and R. Ballotti (1997), Nitric oxide producee by ultraviolet-irradiated keratinocytes stimulates melanogenesis, J. Clin. Invest. 99(4), 635-642   DOI   ScienceOn
13 Kim, S. J., M. Y. Heo, K. H. Son, and Kim Hp (2003), Tyrosinase inhibitory activity of 80 plant extracts (II), J. Appl. Pharmacol. 11, 5-7
14 Lee, H. J., Y. S. Jeong, S. Y. Ryu, and J. H. Ryu (1998), Inhition of nitric oxide synthesis by 8-epi-xanthatin in activated RAW 264.7 cells, Yakhak Hoeji. 42(5), 540-543
15 Sasaki, M., T. Horikoshi, H. Uchiwa, and Y. Miyachi (2000), Up-regulation of tyrosinase gene by nitric oxide in human melanocytes, Pigment. Cell. Res. 13(4), 248-252   DOI   ScienceOn
16 Jung, S. W., N. K. Lee, S. J. Kim, and D. Han (1995), Screening of tyrosinase inhibitior from plants, Kor. J. Food Sci. Technol. 27, 891-896   과학기술학회마을
17 Lee, H. B., S. Bai, and J. E. Chin (2005), Inhibitory Effect of Lithospermum erythrorhizon Extracts on Melanin Biosynthesis, J. Kor. Soc. Food. Sci. Nutr. 34(9), 1325-1329   과학기술학회마을   DOI
18 Solano, F., P. Aroca, C. Salinas, J. C. Gracia-Borron, and J. A. Lozano (1992), Regulation of final phase of melanogenesis, Eur. J. Biochem. 208, 155-163   DOI
19 Suk, K. D., S. J. Lee, and J. M. Bae (2004), Inhibitory Effects of Cuscuta japonica Extract and C. australis Extract on Mushroom tyrosinase Activity, Kor. J. Pharmacogn. 35(4), 380-383   과학기술학회마을
20 Tomita, K., N. Oda, M. Kamel, T. MiyaKi, and T. Oki (1990), Anew screening method for melanin biosynthesis inhibitors using Streptomyces bikiniensis, J. Antibiotics. 12, 1601-1605
21 Stuehr, H. J., N. S. Kwon, M. Weise, and C. Nathan (1991), Purification of the cytokine-induced macrophage nitric oxide synthase : and FAD- and FMN-containing flavoprotein, Proc. Natl. Aca. Sci U.S.A. 88, 7773-7777
22 Hwang, J. S., H. J. Shin, H. S. Noh, H. J Choi, S. M. Ahn, D. S. Park, D. H. Kim, B. G. Lee, I. S. Chang, and H. H. Kang (2002), The inhibitory effects of 3,4,5-Trimethoxy cinnamate thymol ester (TCTE, $Melasolv^{\circledR}$) on Melanogenesis, J. Soc. Cosmet. Sci. Kor. 28(1), 135-149   과학기술학회마을
23 Kim, J. Y. (2006), Studies on the bioactive compounds isolated from Pachydictyon coriaceum and Polygonum cuspidatum, M. S. Thesis, Dept. of Applied Chemistry, Hanbat National University, Daejeon
24 Aroca, P., K. Urabe, K. Kobayashi, K. Taskamoto, and V. J. Hearing (1993), Melanin biosynthesis patterns of following hormonal stimulation, J. Biol. Chem. 268, 25650-25655