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Effect of Mulberry Extracts on Secretion of MMPs and Plasmin in U-373-MG Cells  

Lee, Suk-Hee (Division of Biological Sciences, Research Center of Bioactive Materials, Chonbuk National University)
Kim, Hwan-Gyu (Division of Biological Sciences, Research Center of Bioactive Materials, Chonbuk National University)
Publication Information
KSBB Journal / v.23, no.2, 2008 , pp. 142-146 More about this Journal
Abstract
In order to sprout and migrate, cells must secrete proteinases which are degrading the surrounding extracellular matrix. In this study, we examined the effect of mulberry extracts and combination of mulberry extracts and VEGF on human malignant glioma U-373-MG cells. Mulberry extracts induced the secretion of matrix metalloproteinase-9 (MMP-9) and suppressed the secretion of MMP-2 and plasmin. Mulberry extracts inhibited the VEGF-induced MMP-2, MMP-9 and plasmin secretion. It is therefore, suggested that mulberry extracts can suppress the VEGF-induced tumor angiogenesis in U-373-MG cells. Also, mulberry extracts induced the secretion of MMP-9 and plasmin through PI 3'-kinase pathway in U-373-MG cells.
Keywords
mulberry; MMP; plasmin; VEGF;
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