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Preparation of Water-Soluble Solid Forms Containing Ursolic Acid Using Supercritical Fluid  

Lee, Sang-Yun (Department of Chemical and Biochemical Engineering, The University of Suwon)
Jung, Ju-Hee (Department of Chemical and Biochemical Engineering, The University of Suwon)
Jung, In-Il (Department of Chemical and Biochemical Engineering, The University of Suwon)
Choi, Moon-Jae (Nebion Co., Ltd.)
Park, Eui-Hoon (Nebion Co., Ltd.)
Ryu, Jong-Hoon (Department of Chemical and Biochemical Engineering, The University of Suwon)
Lim, Gio-Bin (Department of Chemical and Biochemical Engineering, The University of Suwon)
Publication Information
KSBB Journal / v.22, no.5, 2007 , pp. 328-335 More about this Journal
Abstract
In this work ursolic acid (UA), a poorly water-soluble compound, was inclusion complexed with 2-hydroxypropyl-$\beta$-cyclodextrin (HP-$\beta$-CD) by various methods such as kneading, solvent evaporation and two types of supercritical fluid processes. The solubility and characteristics of these UA/HP-$\beta$-CD complexes were investigated by scanning electron microscopy, x-ray diffraction and HPLC. The water solubilities of the two complexes obtained from solvent evaporation and ASES processes were observed to increase up to 6$\sim$240 folds and 12$\sim$56 folds, respectively, compared with that of unprocessed UA. The stability of UA/HP-$\beta$-CD complex samples in cosmetic formulations was examined at various temperatures for one month. The UA/HP-$\beta$-CD complex prepared by solvent evaporation was found to be most stable among all the cosmetic formulations tested in our experiments.
Keywords
Ursolic acid; cyclodextrin; solubility; supercritical fluid; stability;
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