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Stability of Vitamin-C Inclusion Comolexes Prepared using a Solvent Evaporation Method  

Yang, Jun-Mo (Department of Chemical and Biochemical Engineering, The University of Suwon)
Lee, Yun-Kyung (Department of Chemical and Biochemical Engineering, The University of Suwon)
Kim, Eun-Mi (Department of Chemical and Biochemical Engineering, The University of Suwon)
Jung, In-Il (Department of Chemical and Biochemical Engineering, The University of Suwon)
Ryu, Jong-Hoon (Department of Chemical and Biochemical Engineering, The University of Suwon)
Lim, Gio-Bin (Department of Chemical and Biochemical Engineering, The University of Suwon)
Publication Information
KSBB Journal / v.21, no.2, 2006 , pp. 151-156 More about this Journal
Abstract
Vitamin-C is one of the typical bioactive substances widely used in the cosmetic and pharmaceutical applications. It is well known that the bioavailability of vitamin-C decreases with time because it is spontaneously oxidized in the presence of oxygen. In this study, vitamin-C inclusion complexes were prepared by formulating vitamin-C with 2-hydroxypropyl-${\beta}$-cyclodextrin (HP-${\beta}$-CD) to protect vitamin-C from being oxidized. Vitamin-C inclusion complexes were prepared by a solvent evaporation method using a rotary evaporator and various solvents of different dielectric constant such as ethanol, methanol and distilled deionized water to investigate the effect of solvent polarity on the stability of vitamin-C. To estimate the stability of inclusion complexes, samples were stored in a 50 mM phosphate buffer solution of pH 7.0 for 24 hours at $25{\pm}0.1^{\circ}C$ and the degradation rate of vitamin-C was calculated using a high performance liquid chromatography. The stability of vitamin-C was observed to improve with the increase of solvent polarity.
Keywords
Vitamin-C; cyclodextrin; inclusion complex; stabilization; solvent evaporation;
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