Browse > Article

A Study on the Extraction and Efficacy of Bioactive Compound from Hovenia dulcis  

Kim Sung-Mun (Department of Chemical Engineering, Kongju National University)
Kang Sung-Hee (Department of Chemical Engineering, Kongju National University)
Ma Jin-Yeul (Korea Institute of Oriental Medicine)
Kim Jin-Hyun (Department of Chemical Engineering, Kongju National University)
Publication Information
KSBB Journal / v.21, no.1, 2006 , pp. 11-15 More about this Journal
Abstract
The biological activities of extracts from the fruit, stem, and leaf of Hovenia dulcis were examined. In the batch mode of operation, the fruit, stem, and leaf of Hovenia dulcis were extracted with hot water for 10 hr. The fruit extract of Hovenia dulcis gave the highest activity for decreasing alcohol concentration which was 138% of control. The equilibrium between bioactive compound in the fruit (size : 4 mm) and hot water solution was reached within 6 hr and the recovery was 95% by three-times extraction. The fruit extract of Hovenia dulcis showed significant alcohol decrease in blood and hepatoprotective activity against $CCl_4$-toxicity in rat. The fruit extract significantly inhibited the elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels.
Keywords
Hovenia dulcis; fruit extract; biological activity; alcohol concentration; hepatoprotective activity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Lee, M. K., Y. G. Kim, S. W. An, M. H. Kim, J. H. Lee, and H. Y. Lee (1999), Biological activities of Hovenia dulcis THUNB, Korean J. Medicinal Crop Sco. 7, 185-192
2 Hong, Y. L., M. H. Kim, C. Ahn, H. Y. Lee, and J. D. Kim (2000), Studies on the biological activities of the extract from Hovenia dulcis $T_{HUNB}$, Inst. Agr. Sci., Kangwon Nat'l. Univ. 11, 1-11
3 Hase, K. and P. Basnet (1997), Effect of Hovenia dulcis on lipopolysaccharide-induced liver injury in chronic alcohol-fed rats, J. Trad. Med. 14, 28-33
4 Sakai, K., T. Yamane, Y. Saitoh, C. Ikawa, and T. Nishihata (1987), Effect of water extracts of crude drugs in decreasing blood alcohol concentrations in rats, Chem. Pharm. Bull. 35, 4597-4604   DOI   ScienceOn
5 Lee, K. J. and K. H. Row (2004), Comparison of extraction methods for aglycone isoflavones from Korean Soybean, Korean J. Biotechonl. Bioeng. 19, 421-426   과학기술학회마을
6 Kim, M. H. and O. H. Kown (1992), Relationship hepatic triglyceride accumulation by ethanol to activity of lipogenic enzymes in rat liver, Korea Biochem. J. 25, 499-503
7 Yohsikawa, M., T. Murakami, T. Ueda, S. Yoshizumi, K. Ninomiya, N. Murakami, H. Matsuda, M. Saito, W. Fujii, T. Tanaka, and J. Yamahara (1997), Bioactive constituents of chinese natural medicines. Absolute stereostructures of new dihydroflavonols, hovenitis I, II and III, isolated from Hovenia semen seu fructus, the seed and fruit of Hovenia dulcis, YAKUGAKU ZASSHI 117, 108-118   DOI
8 Jeong, C. H. and K. H. Shim (1999), Antimicrobial activity of Hovenia dulcis $T_{HUNB}$ leaf and fruit stalk extracts, J. Inst. Agri. & Fishery Develop., Gyeongsang Nat'l. Univ. 18, 25-32
9 Burtist, C. A., E. R. Ashwood (1994), The textbook of clinical chemistry, 2nd ed., p788, WB saunders company, Philadelphia
10 An, S. W., Y. G. Kim, M. H. Kim, B. I. Lee, S. H. Lee, H. I. Kwon, B. Hwang, and H. Y. Lee (1999), Comparision of hepatic detoxification activity and reducing serum alcohol concentration of Hovenia dulcis THUNB and Alnus japonica steud, Korean J. Medicinal Crop Sci. 7, 263-268
11 D.-C. Kim, M.-J. In, and H. J. Chae (2001), Functional foods, Hangchang Press, Seoul, Korea
12 Yohsikawa, M. and T. Murakami (1996), Four methyl-migrated 16,17-seco-dammarane triterpene glycosides from chines natural Medicine, Hovenia semen seu fructus, the seeds and fruit of Hovenia dulcis Thunb, Chem. Pharm. Bull. 44, 1736-1743   DOI   ScienceOn