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Paclitaxel : Recovery and Purification in Commercialization Step  

Kim Jin-Hyun (Department of Chemical Engineering, Kongju National University)
Publication Information
KSBB Journal / v.21, no.1, 2006 , pp. 1-10 More about this Journal
Abstract
The recovery and purification of a paclitaxel from plant cell cultures is essential to commercial process. This review describes a large-scale recovery and purification method for producing paclitaxel, to guarantee high purity and yield from plant cell cultures. Also, the process of separation and purification is optimized in conjunction with a extraction step, pre-purification, purification, and polishing (drying) as an integrated process to meet final product quality requirements such as purity, residual solvents, product morphologies, impurities, bacterial endotoxin, etc. This information is very useful for production and quality control of pharmaceuticals in commercialization step.
Keywords
Paclitaxel; recovery; purification; quality requirement; commercialization;
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