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Chivosazole F, An Efficient Inhibitor of Multidrug-Resistant Cancer Cells Isolated from Sorangium Cellulosum [Myxobacteria]  

Ahn Jong-Woong (Division of Marine Environment & Bioscience, Korea Maritime University)
Choi Sang-Un (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Seo Youngwan (Division of Marine Environment & Bioscience, Korea Maritime University)
Rho Jung-Rae (Department of Marine Information Science, Kunsan National University)
Publication Information
KSBB Journal / v.20, no.5, 2005 , pp. 371-375 More about this Journal
Abstract
In the course of our search for compounds effective to multidrug-resistant cancer cells from myxobacteria with the adriamycin-resistant cancer cell line CL02, we found cytotoxic activity against the CL02 cells in culture extract of Sorangium cellulosum JW1045. Activity-guided fractionation of the culture extract led to the isolation of an active principle, chivosazole F, This compound showed high cytotoxic activity against cultured human cancer cells. The $IC_{50}$ values, measured by a SRB assay with different cell lines, ranged from 0.1 to 10 ng/ml. Furthermore chivosazole F was as active against drug-resistant cancer cells CL02 and CP70 as against the corresponding sensitive cells.
Keywords
Chivosazole F; Sorangium cellulosum; cytotoxicity; mdr-cancer cell;
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