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Effects of Red Ginseng Total Saponin on the Polycystic Ovaries in Rats  

Lee Jiae (Creation and Love Women's Hospital)
Lim Sung-Chul (Department of Pathology and Research Center for Resistant Cells, Chosun University, Medical School)
Lyu Ae-Ran (College of Veterinary Medicine, Chonnam National University)
Bae Jin-Gyu (College of Veterinary Medicine, Chonnam National University)
Kang Seong-Soo (College of Veterinary Medicine, Chonnam National University)
Kim Jong-Choon (College of Veterinary Medicine, Chonnam National University)
Kim Sung-Ho (College of Veterinary Medicine, Chonnam National University)
Kim Jeong-Wook (Creation and Love Women's Hospital)
Choi Bum-Chae (Creation and Love Women's Hospital)
Bae Chun-Sik (College of Veterinary Medicine, Biotechnology Research Institute, Chonnam National University)
Publication Information
KSBB Journal / v.19, no.6, 2004 , pp. 433-436 More about this Journal
Abstract
Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. There are some evidences that nerve growth factor (NGF) is involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng total saponin (GTS) on the ovarian morphology and NGF expressions in the ovaries, pituitary and hippocampus. The oil control animals were injected with 0.2 ml oil/rat. Animals in estradiol valerate (EV) control group were injected i.m. with 4 mg EV in 0.2 ml oil/rat. The GTS was administered (100 mg/kg) i.p. every other day for 60 days, beginning 1 day after the EV injection. PCO was induced by a single injection of EV (4 mg, i.m.). At day 60, the expressions of NGF were examined by immunohistochemistry. The main findings were as follows; PCO was fully developed with a single i.m. injection of EV, and PCO showed the increased expression of NGF, and GTS administration decreased NGF expressions in the ovaries without affecting pituitary and hippocampus significantly. The present results demonstrate that GTS attenuates PCOS by the stimulation of NGF expression.
Keywords
PCO; nerve growth factor; estradiol valerate; saponin; rat;
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