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Release Properties of BSA from Pectin Heads for Colonic Drug Delivery  

최춘순 (광주보건대학 식품생명공학과)
박상무 (전남대학교 의공학협동과정)
송원현 (전남대학교 의공학협동과정)
이창문 (전남대학교 의공학협동과정)
이기영 (화학공학부 및 촉매연구소)
김동운 (광양보건대학 보건위생과)
김진철 (강원대학교 바이오산업공학부)
Publication Information
KSBB Journal / v.18, no.2, 2003 , pp. 161-164 More about this Journal
Abstract
Oral drug delivery system using pectin gel was developed for colon-targeting of peptide drug. BSA(bovine serum albumin)-loaded pectin and pectin-alginate beads were prepared for drug release properties in vitro. Morphological studies by electron microscopy indicated that pectin and pectin-alginate beads were spherical in shape and approximately 1.0 mm. In order to find the suitable beads, effects of cross-linking agents (calcium chloride or zinc acetate) and drying temperature of beads were investigated. Drug release decreased with concentration of cross-linking agents and drying temperature. For colonic drug delivery from pectin and pectin-alginate beads, pectin degradable enzymes were added at 5 hrs from the beginning of drug release. After addition of enzymes, drug release was suddenly increased against free enzymes. Therefore, pectin and pectin-alginate beads can be promised as useful drug release carriers for colon-targeted delivery.
Keywords
Pectin; BSA; colon-target; bead;
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