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Drug Release Characteristics of Biodegradable Polymers for Stent Coating  

강혜수 (충북대학교 화학공학부)
김진설 (충북대학교 화학공학부)
김동운 (의과대학)
강병철 (동의대학교 화학공학과)
이봉희 (충북대학교 화학공학부)
김범수 (충북대학교 화학공학부)
Publication Information
KSBB Journal / v.18, no.2, 2003 , pp. 107-110 More about this Journal
Abstract
Biodegradable polymers, poly(lactic-co-glycolic acid) (PLGA), poly(3-hydroxybutyrate) (PHB), and medium chain length polyhydroxyalkanoates (MCL-PHA) containing rose bengal (model drug) were coated onto the surface of stainless steel (stent materials) and their in vitro release characteristics were investigated. Drug release increased with; decreasing PLGA concentration, increasing rose bengal concentration, and Increasing dip-coating duration. The order of drug release from the polymer coating was: PHB > PLGA > MCL-PHA. These results suggest that drug release can be controlled by: changing the concentration and type of polymer, the drug concentration, and the dip-coating duration.
Keywords
Stent coating; biodegradable polymer; drug release; PLGA; PHA;
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