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Chromatographic Characterization of Pentoxifylline and a Mixture of Caffeine-theophylline Imprinted Polymer  

홍승표 (인하대학교 공과대학 화학공학과)
왕덕선 (인하대학교 공과대학 화학공학과)
구윤모 (초정밀분리기술센터, 인하대학교)
노경호 (인하대학교 공과대학 화학공학과)
Publication Information
KSBB Journal / v.18, no.1, 2003 , pp. 65-69 More about this Journal
Abstract
Two molecular imprinted polymers (MIPs) were prepared by using pentoxifylline and a mixture of caffeine-theophylline (2:1, mole ratio) as the templates, MAA as the monomer, and EDMA as the crosslinker The obtained polymer particles (particle size 25-35 $\mu\textrm{m}$) were packed into a HPLC column (150$\times$3.9mm). The selectivity and chromatographic characterization of the imprinted polymers were studied using pentoxifylline, caffeine, theophylline, theobromine as samples and acetonitrile as the mobile phase, Both imprinted polymers showed increased affinity for structural analogues. By using a mixture of caffeine-theophylline templates MIPs, good separations of caffeine, theobromine and theophylline were obtained, and pentoxifylline and caffeine were partly separated.
Keywords
Molecular imprinting; molecular recognition; hydrogen bond; HPLC;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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