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Effect of Plant Extract [FGF271] on Estrogen Replacement  

김재수 ((주)내츄럴엔도텍)
박준홍 ((주)내츄럴엔도텍)
조한성 ((주)내츄럴엔도텍)
박점석 (강원대학교 바이오산업공학부)
홍억기 (강원대학교 바이오산업공학부)
Publication Information
KSBB Journal / v.17, no.4, 2002 , pp. 409-415 More about this Journal
Abstract
A certain group of phytochemicals such as isoflavone have been proven to act as a phytoestrogen. After thorough the study of different bibliographic herbs excluding soybeans, dates, pomegranates, and other publicized plants, three different edible herbs by Korean Food Regulation were extracted for the animal study on the effect of estrogen replacement. The herbal extract(FGF271) has been orally administered into 51 weeks old partial ovariectomized rats for 5 weeks with the different dosages of 100 and 1,000 mg/kg, respectively. It was observed that 1) serum estrogen level was increased in both 100 and 1,000 mg/kg group, 2) the distension of uterus was made dose dependently and significantly different in 1,000 mg/kg group (p.0.05) from control in the gross findings, 3) the weight of uterus was increased in 1,000 mg/kg group, and 4) the action on reproductive tissues was clear in the microscopic findings in terms of hyperplasia of endometrial epithelial cell, cystic change of submucosa, dilatation of uterus (significantly increased in 1,000 kg/mg), and follicular cystic changes in ovary. As a result, FGF271 seemed to act as a phytoestrogen by inducing the change in ovary and uterus and by increasing the serum estrogen concentration.
Keywords
FGF271; estrogen; phytoestrogen;
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Times Cited By KSCI : 1  (Citation Analysis)
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