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http://dx.doi.org/10.5322/JESI.2019.28.11.943

Influences of Sodium Fluoride Contents on Hepatic Functional Enzyme Activities in Rats  

Kim, Han-Soo (Department of Food Science and Technology, Pusan National University)
Publication Information
Journal of Environmental Science International / v.28, no.11, 2019 , pp. 943-950 More about this Journal
Abstract
The purpose of this study was to probe the influences of NaF oral administration on a dose-effect relationship between fluoride levels of serum enzyme activity such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in rats fed experimental diets for 5 weeks. All groups increased the activity of serum ALP, AST, ALT, and LDH levels with increasing NaF. In addition the fluoride levels of serum and organ tissues (liver, brain, heart, lung, kidney) in oral NaF groups (NF3~NF50) were significantly increased by adding sodium fluoride in comparison with normal diet group (ND) (p<0.05). These results, a high concentration of sodium fluoride was determined that the toxicity to various organ tissues.
Keywords
Sodium fluoride (NaF); Aminotransferase (AST, ALT); Alkaline phosphatase (ALP); Lactate dehydrogenase (LDH);
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1 Vozarova, B., Stefan, N., Lindsay, R. S., Saremi, A., Pratley, R. E., Bogardus, C., Tataranni, P. A, 2002, High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes, Diabetes, 51(6), 1889-1895.   DOI
2 Wang, A. G., Xia, T., Ru, R., Yuan, J., Chen, X., Yang, K., Yang, K., 2004, Antagonistic effect of selenium on oxidative stress, DNA damage, and apoptosis induced by fluoride in human hepatocytes, Fluoride, 37(2), 107-116.
3 Wang, Y. N., Xiao, K. Q., Liu, J. L., Dallner, G., Guan, Z. Z., 2000, Effect of long term fluoride exposure on lipid composition in rat liver, Toxicol., 146(2), 161-169.   DOI
4 Clark, J. M., Brancati, F. L., Diehl, A. M., 2003, The prevalence and etiology of elevated aminotransferase levels in the United States, Am. J. Gastroenterol., 98(5), 960-967.   DOI
5 Decker, T., Lohmann-Matthes, M. L., 1988, A Quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and Tumor Necrosis Factor (TNF) activity, J. Immunol. Meth., 115(1), 61-69.   DOI
6 Dote, T., Kono, K., Usuda, K., Nishiura, H., Tagawa, T., Miyata, K., Shimahara, M., Hashiguchi, N., Senda, J., Tanaka, Y., 2000, Toxicokinetics of intravenous fluoride in rats with renal damage caused by high-dose fluoride exposure, Int. Arch. Occup. Environ. Health, 73(1), S90-S92.   DOI
7 Xiong, X., Liu, J., He, W., Xia, T., He, P., Chen, X., Yang, K., Wang, A., 2007, Dose-effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children, Environ. Res., 103(1), 112-116.   DOI
8 Wergedal, J. E., Baylink, D. J., 1983, Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells, Science, 222(4621), 330-332.   DOI
9 Whitford, G. M., 1994, Intake and metabolism of fluoride, Advances Dental Res., 8(1), 5-14.   DOI
10 Wu, H. J., Chen, K. Y., Shee, B. W., Chang, H. C., Huang, Y. J., Yang, R. S., 2004, Effects of 24 h ultra -marathon on biochemical and hematological parameters, World J. Gastroenterol., 10(18), 2711-2714.   DOI
11 Zabulyte, D., Uleckiene, S., Kalibatas, J., Paltanaviciene, A., Jascaniniene, N., Stosik, M., 2007, Experimental studies on effect of sodium fluoride and nitrate on biochemical parameters in rats, Bull. Vet. Inst. Pulawy, 51(1), 79-82.
12 Gillespie, R. J., Humphries, D. A., Baird, N. C., Robinson, E. A., 1989, Chemistry, second ed. Allyn and Bacon, Boston.
13 Eune, J. J., Lee, E. S., Rim, J. S., Jang, H. S., Woo, H. I., 2005, Changes of serum alkaline phosphatase after enucleation of cysts in the jaws, J. Kor. Assoc. Oral Maxillofac. Surg., 31(5), 417-421.
14 Gessner, B. D., Beller, M., Middaugh, J. P., Whitford, G. M., 1994, Acute fluoride poisoning from a public water system, N. Engl. J. Med., 330(2), 95-99.   DOI
15 Ghosh, D., Das, S., Maiti, R., Jana, D., Das, U. B., 2002, Testicular toxicity in sodium fluoride treated rats: association with oxidative stress, Reprod. Toxicol., 16(4), 385-390.   DOI
16 Hamza, R. Z., El-Shenawy, N. S., Ismail, H. A., 2015, Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat, J. Basic Clin. Physiol. Pharmacol., 26(3), 237-251.   DOI
17 Kim, H. C., Nam, C. M., Jee, S. H., Han, K. H., Oh, D. K., Suh, I., 2004, Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study, BMJ, 328(7446), 983-988.   DOI
18 Jin, D. H., Oh, D. Y., Lee, Y. G., Kang, D. S., Kim, H. S., 2018, Effects of antarctic ocean krill (Euphausia superba) supplementation on hepatic functional enzyme activities and fluoride levels in rats, J. Oil Applied Sci., 35(2), 485-491.   DOI
19 Kato, G. J., McGowan, V., Machado, R. F., Little, J. A., Taylor, J., Morris, C. R., Nichols, J. S., Wang, X., Poljakovic, M., Morris Jr, S. M., Gladwin, M. T., 2006, Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease, Blood, 107(6), 2279-2285.   DOI
20 Kaplan, M. M., Righetti, A., 1970, Induction of rat liver alkaline phosphatase: the mechanism of the serum elevation in bile duct obstruction, J. Clin. Invest., 49(3), 508-516.   DOI
21 Kim, H. S., 2006, Effects of the Saururus chinensis Baill hot-water extract intake on the lipid components and metabolic enzyme activities in hyperlipidemic rats, Kor. J. Exer. Nutr., 10(2), 99-106.
22 Krook, L., Minor, R. R., 1998, Fluoride and alkaline phosphatase, Fluoride, 31(4), 177-182.
23 Kim, H. S., Kim, M. A., Jang, S. H., 2014, Influences of Korean haw (Crataegus pinnatifida Bunge) on lipid concentration in hypercholesterolemia, J. Environ. Sci. Int., 23(5), 793-800.   DOI
24 Kim, K. H., 1980, The clinical application of the result of the test, Ko Moon sa, Seoul, Korea, 164-176.
25 Krishnamachari, K. A., 1985, Skeletal fluorosis in humans: a review of recent progress in the understanding of the disease, Prog. Food Nutr. Sci., 10(3-4), 279-314.
26 Mullenix, P. J., Denbesten, P. K., Schunior, A., Kernan, W. J., 1995, Neurotoxicity of sodium fluoride in rats, Neurotoxicol. Teratol., 17(2), 169-177.   DOI
27 Manivannan, J., Sinha, S., Ghosh, M., Mukherjee, A., 2013, Evaluation of multi-endpoint assay to detect genotoxicity and oxidative stress in mice exposed to sodium fluoride, Mutat. Res., 751(1), 59-65.   DOI
28 Merck index (tenth edition), 1983, Merck Co. Inc., NJ, USA, 8459.
29 Mittal, M., Flora, S. J. S., 2006, Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice, Chem. Biol. Interact., 162(2), 128-139.   DOI
30 Ooi, K., Shiraki, K., Morishita, Y., Nobori, T., 2007, High ‐molecular intestinal alkaline phosphatase in chronic liver diseases, J. Clin. Lab. Anal., 21(3), 133-139.   DOI
31 Urbansky, E. T., 2002, Fate of fluorosilicate drinking water additives, Chem. Rev., 102(8), 2837-2854.   DOI
32 Pollick, H. F., 2013, Water fluoridation and the environment: current perspective in the United States, Int. J. Occup. Environ. Health, 10(3), 343-350.   DOI
33 Reddy, G. B., Khandare, A. L., Reddy, P. Y., Rao, G. S., Balakrishna, N., Srivalli, I., 2003, Antioxidant defense system and lipid peroxidation in patients with skeletal fluorosis and in fluoride-intoxicated rabbits, Toxicol. Sci., 72(2), 363-368.   DOI
34 Singer, L., Ophaug, R., 1979, Total fluoride intake of infants, Pediatrics, 63(3), 460-466.
35 US Public Health Service, 1991, Review of fluoride benefits and risks: executive summary: report of the Ad Hoc subcommittee on fluoride of the committee to coordinate environmental health and related programs, Washington, DC, Dep. Health Human Service, 1-134.
36 Chan, F. K. M., Moriwaki, K., De Rosa, M. J., 2013, Detection of necrosis by release of lactate dehydrogenase activity, Methods. Mol. Biol., 979, 65-70.   DOI
37 Anderson, H. C., Sipe, J. B., Hessle, L., Dhamyamraju, R., Atti, E., Camacho, N. P., Millan, J. L., 2004, Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice, Am. J. Pathol., 164(3), 841-847.   DOI