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http://dx.doi.org/10.5322/JES.2012.21.10.1213

Studies of the Cordyceps militaris Extract Administration on the Metabolic Enzyme Activities in Hypercholesterolemia  

Kim, Han-Soo (Department of Food Science & Technology, Pusan National University)
Kim, Min-A (Department of Food Science & Technology, Pusan National University)
Jang, Seong-Ho (Department of Bioenviromental Energy, Pusan National University)
Kang, Jin-Soon (School of Food Science, International University of Korea)
Lee, Won-Ki (Department of Polymer Engineering, Pukyung National University)
Ryu, Jae-Young (Division for Industrial & Environmental Research, Korea Atomic Energy Research Institute (KAERI))
Publication Information
Journal of Environmental Science International / v.21, no.10, 2012 , pp. 1213-1219 More about this Journal
Abstract
The objective of this study was to investigate the effects of the feeding Cordyceps militaris extract on the improvement of the free fatty acid, lipid peroxide, creatinine and enzyme (creatine phosphokinase; CPK, lactate dehydrogenase; LDH, alkaline phosphatase; ALP, lecithin cholesterol acyltransferase; LCAT) activities in the sera of dietary hypercholesterolemic rats (SD strain, male) fed the experimental diets for 5 weeks. Concentrations of free fatty acid, lipid peroxide and CPK, LDH, ALP activities in sera were fairly reduced in the Cordyceps militaris extract administration group (CHE) than in the hypercholesterolemic diet group (CHD). However, no significance was found in the effect of an creatinine concentration among the groups. The LCAT activity in serum was increased in the Cordyceps militaris extract administration (CHE) than in the hypercholesterolemic diet group (CHD). From these results, Cordyceps militaris extracts were effective on the improvement of the lipid components and metabolic enzyme activities in sera of dietary hypercholesterolemic rats.
Keywords
Cordyceps militaris; Hypercholesterolemia; Lipid peroxide; Metabolic enzyme activities;
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