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http://dx.doi.org/10.5292/jkbjts.2013.19.1.14

Inflammatory Myofibroblastic Tumor of Extremities  

Kong, Chang-Bae (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Lee, Jeong-Dong (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Lee, Jung Uk (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Song, Won-Seok (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Cho, Wan-Hyeong (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Koh, Jae-Soo (Department of Pathology, Korea Cancer Center Hospital)
Jeon, Dae-Geun (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Publication Information
The Journal of the Korean bone and joint tumor society / v.19, no.1, 2013 , pp. 14-19 More about this Journal
Abstract
Purpose: We analyzed the oncologic characteristics and outcome of patients with inflammatory myofibroblastic tumor of extremities. Materials and Methods: Among the soft tissue tumor patients who were treated between 1999 and 2012, 5 patients who were pathologically confirmed as the inflammatory myofibroblastic tumor of extremities were analyzed retrospectively. Results: There were 1 man and 4 women with mean age of 44 years (37-55 years). The average follow up was 34.6 months (8-87 months). All patients underwent surgical treatment. Only 1 patient had wide resection margin and remaining 4 had marginal (3) or intralesional (1) resection margin. All of 4 patients without wide resection margin developed local recurrence at 10.3 months (8-19 months). Malignant transformation to fibrosarcoma was occurred in 2 patients who developed local recurrence, and 1 patient developed multiple metastases to lung, liver and lymph nodes and expired at 37 months. Three of 5 patients had tumor location abutted to or invasion to major arteries and 1 patient had tumor invading sciatic nerve. Conclusion: It is observed that inflammatory myofibroblastic tumor of extremities is usually located near the major neurovascular structure. Wide resection should be considered as the initial surgical treatment because this tumor showed a high local recurrence rate and possibility of malignant transformation.
Keywords
inflammatory myofibroblastic tumor; extremities; margin; wide resection;
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