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http://dx.doi.org/10.5292/jkbjts.2012.18.1.14

Malignant Transformation of Benign Giant Cell Tumor  

Kong, Chang-Bae (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Hong, Yun-Suk (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Lee, Kwang-Youl (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Cho, Sang-Hyun (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Song, Won-Seok (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Cho, Wan-Hyeong (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Koh, Jae-Soo (Department of Orthopedic Pathology, Korea Cancer Center Hospital)
Jeon, Dae-Geun (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
Publication Information
The Journal of the Korean bone and joint tumor society / v.18, no.1, 2012 , pp. 14-19 More about this Journal
Abstract
Purpose: We analyzed the oncologic outcome of the malignant transformed benign giant cell tumor of bone. Materials and Methods: Between January 2000 and February 2012, 5 cases were referred with suspicious malignant transformation of benign giant cell tumor. No patients underwent radiation therapy. Results: After referral, all patients received the wide excision of the tumor and its' pathologic diagnosis were osteosarcoma. As classified by the location of tumor lesion, 3 cases were located in the distal femur, 1 case was in the distal radius and 1 case was in the proximal femur. The average latent period between diagnosis of benign giant cell tumor and diagnosis of secondary malignant giant cell tumor was 49.2 months. (range, 24-126 months) The mean follow-up period was 21.6 months. There were subsequent local recurrence in 2 cases and 3 patients developed distant metastasis. All patients with lung metastasis were dead. Conclusion: Malignant transformation of benign giant cell tumor of bone can be occurred within 5 years. Therefore, when benign giant cell tumor suspicious malignant transformation, it is necessary to do more aggressive treatment.
Keywords
giant cell tumor; malignant transformation; osteosarcoma;
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