Browse > Article
http://dx.doi.org/10.5292/jkbjts.2010.16.2.62

Liposarcoma in the Extremity  

Lee, Soo-Hyun (Department of Orthopedic Surgery, Yonsei University College of Medicine)
Cho, In-Je (Department of Orthopedic Surgery, Yonsei University College of Medicine)
Yang, Woo-Ick (Department of Pathology, Yonsei University College of Medicine)
Suh, Jin-Suck (Department of Radiology, Yonsei University College of Medicine)
Shin, Kyoo-Ho (Department of Orthopedic Surgery, Yonsei University College of Medicine)
Publication Information
The Journal of the Korean bone and joint tumor society / v.16, no.2, 2010 , pp. 62-68 More about this Journal
Abstract
Purpose: We analyzed disease free survival and the prognostic factors of liposarcoma in the extremity. Materials and Methods: Between 1994 and 2005, of 44 patients who were diagnosed and treated for liposarcoma of the extremity, 40 patients were restrospectively analysed. 13 out of 40 patients got postoperative radiotherapy. We examined local recurrence, distant metastasis and disease free 5-year survival rate. We also analyzed clinical prognostic factors, such as age, gender, size of tumor, prior unplanned excision, histologic type, surgical excision margin and postoperative radiotherapy respectively. Results: There were 3 cases of local recurrence and 4 cases of distant metastasis. The disease free 5-year survival rate was 85.0%. 26 patients presented with myxoid, 8 well differentiated, 4 round cell, 1 pleomorphic and 1 dedifferentiated histology. The disease free 5-year survival rate of mixoid, well differentiated and round cell liposarcoma were 100.0%, 84.6% and 75.0% (p=0.419). The 5-year disease free survival rate was 90.6% in negative surgical margin (n=25) and 62.5% in positive surgical margin (n=15) (p=0.003). Conclusion: Our study suggests that surgical excision margin is significant prognostic factor for 5-year disease free survival rate.
Keywords
extremity; liposarcoma; disease free 5-year survival rate; prognostic factor;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Dei Tos AP. Liposarcoma: new entities and evolving concepts. Ann Diagn Pathol. 2000;4:252-66.   DOI   ScienceOn
2 Fletcher CDM, Unni KK, Mertens F. World Health Organization classification of tumors: pathology and genetics of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2002. 35-46.
3 Kim HS, Lee J, Yi SY, et al. Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy. BMC Cancer. 2009;9:205.   DOI   ScienceOn
4 Lee SY, Jeon DG, Kim SS. Clinical analysis of liposarcoma. J Korean Orthop Assoc. 1993;28:454-8.
5 Singer S, Antonescu CR, Riedel E, Brennan MF. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 2003;238:358-70.
6 Smith TA, Easley KA, Goldblum JR. Myxoid/round cell liposarcoma of the extremities. A clinicopathologic study of 29 cases with particular attention to extent of round cell liposarcoma. Am J Surg Pathol. 1996;20:171-80.   DOI   ScienceOn
7 Pisters PW, Harrison LB, Woodruff JM, Gaynor JJ, Brennan MF. A prospective randomized trial of adjuvant brachytherapy in the management of low-grade soft tissue sarcomas of the extremity and superficial trunk. J Clin Oncol. 1994;12:1150-5.   DOI
8 Loubignac F, Bourtoul C, Chapel F. Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance. World J Surg Oncol. 2009;7:42.   DOI
9 Weiss SW, Goldblum JR. Eizinger and Weiss's soft tissue tumours. 4th ed. St. Louis: Mosby; 2001.
10 Ng YCS, Tan MH. Liposarcoma of the extremities: a review of the cases seen and managed in a major tertiary hospital in Singapore. Singapore Med J. 2009;50:857-61.
11 Antonescu CR, Tschernyavsky SJ, Decuseara R, et al. Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases. Clin Cancer Res. 2001;7:3977-87.
12 Issakov J, Soyfer V, Kollender Y, et al. Liposarcoma in adult limbs treated by limb-sparing surgery and adjuvant radiotherapy. J Bone Joint Surg Br. 2006;88:1647-51.   DOI   ScienceOn
13 Chung PW, Deheshi BM, Ferguson PC, et al. Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: a comparison with other soft tissue sarcomas. Cancer. 2009;115:3254-61.   DOI   ScienceOn
14 Yang JC, Chang AE, Baker AR, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16:197-203.
15 Linehan DC, Lewis JJ, Leung D, Brennan MF. Influence of biologic factors and anatomic site in completely resected liposarcoma. J Clin Oncol. 2000;18:1637-43.   DOI
16 Evans HL. Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol. 1979;3:507-23.   DOI   ScienceOn
17 Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225-49.   DOI   ScienceOn
18 Chang HR, Gaynor J, Tan C, Hajdu SI, Brennan MF. Multifactorial analysis of survival in primary extremity liposarcoma. World J Surg. 1990;14:610-8.   DOI   ScienceOn
19 Fiore M, Grosso F, Lo Vullo S, et al. Myxoid/round cell and pleomorphic liposarcomas: prognostic factors and survival in a series of patients treated at a single institution. Cancer. 2007;109:2522-31.   DOI   ScienceOn