Quantitative Label-free Terahertz Sensing of Transdermal Nicotine Delivered to Human Skin |
Lee, Gyuseok
(Department of Electrical Engineering, Pohang University of Science and Technology)
Namkung, Ho (Department of Electrical Engineering, Pohang University of Science and Technology) Do, Youngwoong (Department of Electrical Engineering, Pohang University of Science and Technology) Lee, Soonsung (Department of Electrical Engineering, Pohang University of Science and Technology) Kang, Hyeona (Department of Electrical Engineering, Pohang University of Science and Technology) Kim, Jin-Woo (Department of Electrical Engineering, Pohang University of Science and Technology) Han, Haewook (Department of Electrical Engineering, Pohang University of Science and Technology) |
1 | R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, "Terahertz pulse imaging of ex vivo basal cell carcinoma," J. Invest. Dermatol. 120, 72-78 (2003). DOI |
2 | S. W. Smye, J. M. Chamberlain, A. J. Fitzgerald, and E. Berry, "The interaction between Terahertz radiation and biological tissue," Phys. Med. Biol. 46, R101 (2001). DOI |
3 | E. Jung, H.-J. Choi, M. Lim, H. Kang, H. Park, H. Han, B.-H. Min, S. Kim, I. Park, and H. Lim, "Quantitative analysis of water distribution in human articular cartilage using terahertz time-domain spectroscopy," Biomed. Opt. Express 3, 1110-1115 (2012). DOI |
4 | E. Jung, H. Park, K. Moon, M. Lim, Y. Do, H. Han, H. J. Choi, B.-H. Min, S. Kim, I. Park, and H. Lim, "THz timedomain spectroscopic imaging of human articular cartilage," J. Infrared, Millimeter, Teraherz Waves 33, 593-598 (2012). DOI |
5 | E.-A. Jung, M.-H. Lim, K.-W. Moon, Y.-W. Do, S.-S. Lee, H.-W. Han, H.-J. Choi, K.-S. Cho, and K.-R. Kim, "Terahertz pulse imaging of micro-metastatic lymph nodes in early-stage cervical cancer patients," J. Opt. Soc. Korea 15, 155-160 (2011). DOI |
6 | P. C. Ashworth, E. Pickwell-MacPherson, E. Provenzano, S. E. Pinder, A. D. Purushotham, M. Pepper, and V. P. Wallace, "Terahertz pulsed spectroscopy of freshly excised human breast cancer," Opt. Express 17, 12444-12454 (2009). DOI |
7 | M. R. Prausnitz and R. Langer, "Transdermal drug delivery," Nat. Biotechnol. 26, 1261-1268 (2008). DOI |
8 | Z. D. Taylor, R. S. Singh, M. O. Culjat, J. Y. Suen, W. S. Grundfest, H. Lee, and E. R. Brown, "Reflective terahertz imaging of porcine skin burns," Opt. Lett. 33, 1258-1260 (2008). DOI |
9 | K. W. Kim, H. Kim, J. Park, J. K. Han, and J.-H. Son, "Terahertz tomographic imaging of transdermal drug delivery," IEEE Trans. Terahertz Sci. Technol. 2, 99-106 (2012). DOI |
10 | J. Wu, K. S. Paudel, C. Strasinger, D. Hammell, A. L. Stinchcomb, and B. J. Hinds, "Programmable transdermal drug delivery of nicotine using carbon nanotube membranes," Proc. Natl. Acad. Sci. U.S.A. 107, 11698-11702 (2010). DOI |
11 | OECD, "Section 4: Health Effects," in OECD Guidelines for the Testing of Chemicals (OECD, 2004), Test NO. 428. |
12 | T. J. Franz, "Percutaneous absorption. On the relevance of in vitro data," J. Invest. Dermatol. 64, 190-195 (1975). DOI |
13 | OECD, "Section 4: Health Effects," in OECD Guidelines for the Testing of Chemicals (OECD, 2004), Test NO. 427. |
14 |
Nicoderm CQ |
15 | Y.-S. Jin, G.-J. Kim, and S.-G. Jeon, "Terahertz dielectric properties of polymers," J. Korean Phys. Soc. 49, 513-517 (2006). |
16 | Advameg, Inc., Nicotine patch (How Products Are Made), http://www.madehow.com/Volume-3/Nicotine-Patch.html#ixzz47mtvWygA (Accessed date: 14 May 2020). |
17 | S. L. Chuang, Physics of Photonic Devices, 2nd ed. (John Wiley&Sons, NJ, USA, 2009), pp. 202-220. |
18 | B. Yu, Z. Huang, X.-Y. Wang, and G.-Z. Zhao, "Study on THz spectra of nicotinic acid, nicotinamide and nicotine," Spectrosc. Spectral Anal. 29, 2334-2337 (2009). DOI |
19 | S. K. Gupta, N. L. Benowitz, P. Jacob 3rd, C. N. Rolf, and J. Gorsline, "Bioavailability and absorption kinetics of nicotine following application of a transdermal system," Br. J. Clin. Pharmacol. 36, 221-227 (1993). DOI |
![]() |