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http://dx.doi.org/10.3807/KJOP.2019.30.6.243

Three-dimensional Imaging with an Endoscopic Optical Coherence Tomography System for Detection of Airway Stenosis  

Kwon, Daa young (Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology, Pukyong National University)
Oak, Chulho (Innovative Biomedical Technology Research Center)
Ahn, Yeh-Chan (Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology, Pukyong National University)
Publication Information
Korean Journal of Optics and Photonics / v.30, no.6, 2019 , pp. 243-248 More about this Journal
Abstract
The respiratory tract is an essential part of the respiratory system involved in the process of respiration. However, if stenosis occurs, it interferes with breathing and can even lead to death. Asthma is a typical example of a reversible cause of airway narrowing, and the number of patients suffering from acute exacerbation is steadily increasing. Therefore, it is important to detect airway narrowing early and prevent the patient's condition from worsening. Optical coherence tomography (OCT), which has high resolution, is suitable for observing the microstructure of tissues. In this study we developed an endoscopic OCT system. We combined a 1300-nm OCT system with a servo motor, which can rotate at a high speed. A catheter was pulled back using a linear stage while imaging with 360° rotation by the motor. The motor was selected considering various requirements, such as torque, rotational speed, and gear ratio of pulleys. An ex vivo rabbit tracheal model was used as a sample, and the sample and catheter were immobilized by acrylic structures. The OCT images provided information about the structures of the mucosa and submucosa. The difference between normal and stenosed parts in the trachea was confirmed by OCT. Furthermore, through a three-dimensional (3-D) reconstruction process, it was possible to identify and diagnose the stenosis in the 3-D image of the airway, as well as the cross-sectional image. This study would be useful not only for diagnosing airway stenosis, but also for realizing 3-D imaging.
Keywords
Endoscopic optical coherence tomography; Airway stenosis; Servo motor; 3-dimensional image reconstruction;
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1 The Korean Center for Disease Classification and Information, "Disease statistics section," (KOICD Centers for Disease Classification and Information), http://www.koicd.kr/2016/stats/diseaseStats.do (2019.04.15.).
2 G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996).   DOI
3 P. H. Tomlins and R. K. Wang, "Theory, developments and applications of optical coherence tomography," J. Phys. D: Appl. Phys. 38, 2519 (2005).   DOI
4 N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, "Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura," J. Thorac. Cardiovasc. Surg. 129, 615-622 (2005).   DOI
5 G. K. Sharma, G. S. Ahuja, M. Wiedmann, K. E. Osann, E. Su, A. E. Heidari, J. C. Jing, Y. Qu, F. Lazarow, A. Wang, L. Chou, C. C. Uy, V. Dhar, J. P. Cleary, N. Pham, K. Huoh, Z. Chen, and B. J.-F. Wong, "Long-range optical coherence tomography of the neonatal upper airway for early diagnosis of intubation-related subglottic injury," Am. J. Respir. Crit. Care Med. 192, 1504-1513 (2015).   DOI
6 H. S. Cho, S.-J. Jang, K. Kim, A. V. Dan-Chin-Yu, M. Shishkov, B. E. Bouma, and W.-Y. Oh, "High frame-rate intravascular optical frequency-domain imaging in vivo," Biomed. Opt. Express 5, 223-232 (2014).   DOI
7 J. Y. Ha and S. W. Lee, "Optical coupling device for OCT system," Korea Patent 10-1658447 (2016).
8 H. Pahlevaninezhad, A. M. D. Lee, A. Ritchie, T. Shaipanich, W. Zhang, D. N. Ionescu, G. Hohert, C. MacAulay, S. Lam, and P. Lane, "Endoscopic doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature," Biomed. Opt. Express 6, 4191-4199 (2015).   DOI
9 Z. Yaqoob, J. Wu, E. J. McDowell, X. Heng, and C. Yang, "Methods and application areas of endoscopic optical coherence tomography," J. Biomed. Opt. 11, 063001 (2006).   DOI
10 Y.-C. Ahn, W. Jung, and Z. Chen, "Optical sectioning for microfluidics: secondary flow and mixing in a meandering microchannel," Lab. Chip 8, 125-133 (2008).   DOI
11 V. M. Gelikonov, G. V. Gelikonov, and P. A. Shilyagin, "Linear-wavenumber spectrometer for high-speed spectraldomain optical coherence tomography," Opt. Spectrosc. 106, 459-465 (2009).   DOI
12 S.-W Lee, H.-W. Jeong, B.-M. Kim, Y.-C. Ahn, W. Jung, and Z. Chen, "Optimization for axial resolution, depth range, and sensitivity of spectral domain optical coherence tomography at 1.3 ${\mu}$m," J. Korean Phys. Soc. 55, 2354-2360 (2009).   DOI
13 H. S. Cho, S.-J. Jang, and W.-Y. Oh, "Development of a high-speed endoscopic OCT system and its application to three-dimensional intravascular imaging in vivo," Korean J. Opt. Photon. 25, 67-71 (2014).   DOI
14 H. S. Lee, S. W. Kim, C. Oak, H. W. Kang, J. Oh, M. J. Jung, S. B. Kim, J. H. Won, and K. D. Lee, "Rabbit model of tracheal stenosis using cylindrical diffuser," Lasers Surg. Med. 49, 372-379 (2017).   DOI
15 B. G. Muller, R. A. A. van Kollenburg, A. Swaan, E. C. H. Zwartkruis, M. J. Brandt, L. S. Wilk, M. Almasian, A. W. Schreurs, D. J. Faber, L. R. Rozendaal, A. N. Vis, J. A. Nieuwenhuijzen, J. R. J. A. van Moorselaar, J. J. M. C. H. de la Rosette, D. M. de Bruin, and T. G. van Leeuwen, "Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients," J. Biomed. Opt. 23, 086001 (2018).
16 T. Wang, W. Wieser, G. Springeling, R. Beurskens, C. T. Lancee, T. Pfeiffer, A. F. W. V. D. Steen, R. Huber, and G. V. Soest, "Intravascular optical coherence tomography imaging at 3200 frames per second," Opt. Lett. 38, 1715-1717 (2013).   DOI
17 A. A. Gurjarpadhye, M. R. DeWitt, Y. Xu, G. Wang, M. N. Rylander, and C. G. Rylander, "Dynamic assessment of the endothelialization of tissue-engineered blood vessels using an optical coherence tomography catheter-based fluorescence imaging system," Tissue Eng. Part C 21, 758-766 (2015).   DOI