Browse > Article
http://dx.doi.org/10.3807/KJOP.2017.28.4.158

Photoacoustic Nonlinearity to Absorption Coefficients in Photoacoustic Imaging with Focused Ultrasound Transducers  

Kang, Dongyel (School of Basic Sciences, College of Engineering, Hanbat National University)
Publication Information
Korean Journal of Optics and Photonics / v.28, no.4, 2017 , pp. 158-165 More about this Journal
Abstract
The physical shape of an ultrasound transducer has not been considered in previous studies of the photoacoustic saturation effect, where a photoacoustic signal's magnitude linearly increases as an absorption coefficient increases and it is finally saturated. In this paper, the effect of a spherically focused ultrasound transducer on photoacoustic nonlinearity is investigated. The focused ultrasound transducer's spatial filtering effect on photoacoustic signals is analytically derived considering the combined concept of a virtual point detector and Green function approach. The ultrasound transducer's temporal response (i.e., transfer function) effect on photoacoustic signals is considered by integrating photoacoustic signal values within the absorption area covered by a spatial resolution of the ultrasound transducer. Results from the analytically derived expression show that the magnitude of photoacoustic signals measured by a spherical focused ultrasound transducer shows a maximum at a specific absorption coefficient, and decreases after that maximum point as an absorption coefficient is increased. The origin of this photoacoustic nonlinearity is physically understood by comparing the ultrasound transducer's transfer functions and photoacoustic resonance spectra. In addition, this physical interpretation implies that the photoacoustic nonlinearity is strongly dependent on the irradiance distribution inside an absorption medium.
Keywords
Photoacoustic imaging; Optics; Photoacoustic resonance; Photoacoustic nonlinearity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 G. J. Diebold, T. Sun, and M. I. Khan, "Photoacoustic monopole radiation in one, two, and three dimensions," Phys. Rev. Lett. 67, 3384-3387 (1991).   DOI
2 H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, "Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging," Nat. Biotechnol. 24, 848-851 (2006).   DOI
3 K. Maslov, H. F. Zhang, and L. V. Wang, "Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo," Inverse Probl. 23, S113-S122 (2007).   DOI
4 B. Ning, M. J. Kennedy, A. J. Dixon, N. Sun, R. Cao, B. T. Soetikno, R. Chen, Q. Zhou, K. K. Shung, J. A. Hossack, and S. Hu, "Simultaneous photoacoustic microscopy of microvascular anatomy, oxygen saturation, and blood flow," Opt. Lett. 40, 910-913 (2015).   DOI
5 D. Kang, Q. Huang, and Y. Li, "Measurement of cardiac output by use of noninvasively measured transient hemodilution curves with photoacoustic technology," Biomed. Opt. Express 5, 1445-1452 (2014).   DOI
6 M. Sivaramakrishnan, K. Maslov, H. F. Zhang, G. Stoica, and L. V. Wang, "Limitations of quantitative photoacoustic measurement of blood oxygenation in small vessels," Phys. Med. Biol. 52, 1349-1361 (2007).   DOI
7 J. Wang, T. Liu, S. Jiao, R. Chen, Q. Zhou, K. K. Shung, L. V. Wang, and H. F. Zhang, "Saturation effect in functional photoacoustic imaging," J. Biomed. Opt. 15, 021317 (2010).   DOI
8 D. Kang, B. Lashkari, and A. Mandelis, "Photoacoustic resonance by spatial filtering of focused ultrasound transducers," Opt. Lett. 42, 655-658 (2017).   DOI
9 D. Kang, "Effect of spatial filtering of ultrasound transducers on photoacoustic measurements," Proc. SPIE 10064, 100645D (2017).
10 J. Yao and L. V. Wang, "Photoacoustic microscopy," Laser Photonics Rev. 7, 758-778 (2013).   DOI
11 B. Lashkari and A. Mandelis, "Linear frequency modulation photoacoustic radar: optimal bandwidth and signal-to-noise ratio for frequency-domain imaging of turbid media," J. Acoust. Soc. Am. 130, 1313-1324 (2011).   DOI
12 Z. Li, H. Li, Z. Zeng, W. Xie, and W. R. Chen, "Determination of optical absorption coefficient with focusing photoacoustic imaging," J. Biomed. Opt. 17, 061216 (2012).   DOI
13 Z. Guo, S. Hu, and L. V. Wang, "Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue," Opt. Lett. 35, 2067-2069 (2010).   DOI
14 B. Cox, J. G. Laufer, S. R. Arridge, and P. C. Beard, "Quantitative spectroscopic photoacoustic imaging: a review," J. Biomed. Opt. 17, 061202 (2012).   DOI