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http://dx.doi.org/10.3807/KJOP.2013.24.6.338

Optical Analysis for the Estimation of Whole Blood Coagulation Time with Magnetic Particles  

Lee, Jaehyun (Department of Physics, Hallym University)
Choi, Hyoungsoon (Department of Physics, Hallym University)
Jang, Dongwoo (Department of Physics, Hallym University)
Nahm, Kie B. (Department of Physics, Hallym University)
Publication Information
Korean Journal of Optics and Photonics / v.24, no.6, 2013 , pp. 338-341 More about this Journal
Abstract
Prothrombin Time (PT) is used as a measure of blood coagulation time. An optical analysis of the signal generating mechanism is described here for the reflection-type arrangement. Thromboplastin added into serum or whole blood initiates the coagulation process. We added a sufficient amount of magnetic particles into the sample before adding thromboplastin and subjected the mixture to a rotating magnetic field. The laser light gets reflected in a periodically modulated fashion with respect to the magnetic field rotation. Analysis of this decaying modulation could produce a reasonable coagulation time. We also introduce a simulation model to explain the signal generating mechanism using LightTools.$^{TM}$
Keywords
Prothrombin time; Blood coagulation; Magnetic particle; Liquid surface model; Stray light simulation;
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