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Dietary Effect of Silk Protein on Colon Cancer of Animal  

Yeo, Joo-Hong (Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA)
Lee, Kwang-Gill (Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA)
Woo, Soon-Ok (Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA)
Kweon, Hae-Yong (Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA)
Han, Sang-Mi (Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA)
Park, Kyung-Ho (Graduate School of East-West Medical Science, Kyung Hee University)
Kim, Sung-Su (Department of Anatomy, Chung-Ang University)
Publication Information
Journal of Sericultural and Entomological Science / v.49, no.2, 2007 , pp. 67-70 More about this Journal
Abstract
This study was done for the dietary effect of silk protein, molecular controlled silk sericin and silk fibroin, on colon cancer of animal. The ICR mice were given weekly injections of 1,2-dimethylhydrazine (DMZ) for the initial 10 mg/kg with four weeks, and fed a diets supplemented with 3% (v/v) molecular controlled sericin and fibroin for 6 weeks, respectively. Then, the body weight, efficiency of dietary, typical histologic appearance of animal colon tissue and COX-2 effect were studied, too. Molecular controlled sericin protein are shown more higher dietary effect on animal colon cancer than fibroin supplemental case. The results suggest a potential usefulness of sericin as a chemopreventive for colon carcinogenesis and the development functional food.
Keywords
Silk protein; Sericin; Fibroin; Dietary effect; Animal colon cancer;
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Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
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