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Antioxidant and Anti-Adipogenic Effects of Ethanolic Extracts from Ixeris dentata Nakai  

Park, Sung-Jin (Dept. of Tourism Food Service Cuisine, Hallym Polytechnic University, Research Institute of Biomaterial, Hallym Polytechnic University)
Publication Information
Culinary science and hospitality research / v.20, no.1, 2014 , pp. 133-142 More about this Journal
Abstract
The aim of this study was to evaluate the total phenol, total flavonoids contents and antioxidant activity of 80% ethanolic extract from Ixeris dentata Nakai(IDE) as well as to assess the lipid accumulation during adipogenesis of 3T3-L1 cells. The results demonstrated that the total phenolic and flavonoids contents of the IDE were $4.01{\pm}0.63$ GAE mg/g and $0.05{\pm}0.01$ RE mg/g, respectively. The antioxidative activities of the IDE were significantly increased in a dose dependent manner on DPPH(1,1-Diphenyl-2-picrylhydrazyl) radical scavenging, ABTS(2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt) radical scavenging, reducing power value. During adipocyte differentiation, IDE significantly inhibited lipid accumulation compared with the control cells. These results indicated that the anti-adipogenesis effect of Ixeris dentata Nakai could be attributed to phenolic compounds that may potentially inhibit ROS(reactive oxygen species) production.
Keywords
Ixeris dentata Nakai; 3T3-L1 adipocyte; anti-obesity activity; antioxidant;
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