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http://dx.doi.org/10.7732/kjpr.2021.34.6.503

Undaria pinnatifida Inhibits the Mast Cell-Mediated Inflammatory Response via NF-κB/Caspase-1 Suppression  

Jeon, Yong-Deok (Department of Korean Pharmacy, Woosuk University)
Lee, Su-Hyun (Department of Biotechnology and Convergence, Daegu Haany University)
Kim, Su-Jin (Department of Biotechnology and Convergence, Daegu Haany University)
Publication Information
Korean Journal of Plant Resources / v.34, no.6, 2021 , pp. 503-509 More about this Journal
Abstract
Marine sources as potential treatment options for various diseases have been a subject of growing interest. However, information on the anti-inflammatory mechanism employed by Undaria pinnatifida (UP) remains limited. The present study was conducted to investigate the mechanisms of UP on the mast cell-mediated inflammatory response. To determine the pharmacological mechanism of UP in inflammatory reaction, we evaluated the effects of UP on interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α production and nuclear factor-κB (NF-κB) and caspase-1 activation in calcium ionophore A23187 plus phorbol 12-myristate 13-acetate-stimulated human mast cells-1 (HMC-1). The results showed that UP suppressed IL-6, IL-8 and TNF-α production in a dose-dependent manner. Moreover, UP significantly attenuated NF-kB/caspase-1 activation in stimulated HMC-1. Collectively, these findings provide experimental evidence that UP may be a useful candidate for the inflammation-related diseases treatment.
Keywords
Caspase-1; Inflammation; Inflammatory cytokines; Mast cells; Nuclear factor-${\kappa}B$; Undaria pinnatifida;
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