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http://dx.doi.org/10.7732/kjpr.2021.34.4.368

Tyrosinase Inhibitory Activity and Melanin Production Inhibitory Activity of Taraxinic Acid from Taraxacum coreanum  

Park, Seung Il (C&B BIO Co. Ltd)
Yoon, Hye Ryeon (C&B BIO Co. Ltd)
Shin, Jun-Ho (Gyeonggido Business & Science Accelerator, Bio-center)
Lee, Sung Joo (Department of Environmental Energy Engineering, Anyang University)
Kim, Do Yoon (Division of Cosmetic and Biotechnology, Hoseo University)
Lee, Hwan Myung (Division of Cosmetic and Biotechnology, Hoseo University)
Publication Information
Korean Journal of Plant Resources / v.34, no.4, 2021 , pp. 368-376 More about this Journal
Abstract
This study was to investigate the Taraxinic acid from Taraxacum coreanum on tyrosinase activity and melanogenesis. In B16BL6 cell, Taraxinic acid did not show cytotoxicity even at concentrations of up to 100 ㎍/mL. In addition, tyrosinase inhibitory activity and melanogenesis inhibitory activity were confirmed by stimulation with α-melanocyte stimulating hormone (α-MSH) in the presence of taraxinic acid. Taraxinic acid was added to cells at concentrations of 10, 50 and 100 ㎍/mL and treated for 48 hours to confirm tyrosinase inhibitory activity and melanin production. The tyrosinase inhibitory activity increased in proportion to the amount of the sample, and showed an inhibitory activity of about 54.5% at a concentration of 50 ㎍/mL. Melanin production decreased in proportion to the sample amount, and it was about 62.2% at the concentration of 10 ㎍/mL. From the above results, it was found that Taraxinic acid had higher tyrosinase activity and melanin synthesis inhibitory activity in melanocyte than arbutin. The results suggest that Taraxinic acid can be utilized in natural whitening cosmetics.
Keywords
Melanin; Taraxacum coreanum; Taraxinic acid; Tyrosinase; Whitening;
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