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http://dx.doi.org/10.7732/kjpr.2021.34.1.037

Whitening and Antioxidant Effects of Extracts from Angelica gigas Nakai Thin Root  

Lee, Sang-Hoon (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Park, Jeong-Yong (Herbal Crop Utilization Research Team, National Institute of Horticultural & Herbal Science, RDA)
Seo, Kyung Hye (Floriculture Research Division, National Institute of Horticultural & Herbal Science, RDA)
Choi, Jang Nam (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Lee, Yoon-Jeong (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Moon, Youn-Ho (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Hur, Mok (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Park, Woo Tae (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Huh, Yun Chan (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Chang, Jae-Ki (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Koo, Sung Cheol (Herbal Crop Research Division, National Institute of Horticultural & Herbal Science, RDA)
Publication Information
Korean Journal of Plant Resources / v.34, no.1, 2021 , pp. 37-43 More about this Journal
Abstract
Angelica gigas Nakai (AGN) is a perennial plant belonging to the family Apiaceae. Its root has been utilized as a traditional medicine especially in Korea. This study was carried out to evaluate the potential use of extracts from AGN root parts as a cosmetic material. The dried AGN roots are divided into body (B), thick root (TkR), medium root(MR) and thin root (TnR) according to their diameter before cutting into medicine. B, TkR and MR of AGN are combined and used as medicinal herbs (MH). The extracts from AGN each root part (B, TkR, MR, TnR, MH) were used to test the effect on cell viability using MTS assay and to examine inhibitory effect on melanin accumulation in B16F10 melanoma cells. All extracts (50 - 200 ㎍/mL) from the each root part did not affect the cell viability. And inhibitory effect of all root extracts (200 ㎍/mL) on melanin accumulation was 12-19%. Especially, TnR showed similar inhibitory effect on melanin accumulation to MH. In addition, DPPH and ABTS free radical scavenging activity were higher in the TnR extract compared to MH. This study showed that the TnR extract exhibit high inhibitory effect on melanin accumulation and antioxidant activity compared to MH, suggesting that TnR extract has potential as a cosmetic ingredient.
Keywords
Angelica gigas Nakai; Antioxidant activity; Melanin; Thin root;
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Times Cited By KSCI : 5  (Citation Analysis)
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