Browse > Article
http://dx.doi.org/10.7732/kjpr.2021.34.1.031

Anti-inflammatory Effect of Berchemia berchemiaefolia Leaves through Inhibition of NF-κB and MAPK Signaling Activation in LPS-stimulated RAW264.7 Cells  

Kim, Da Som (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Eo, Hyun Ji (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Kang, Yeongyeong (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Park, Gwang Hun (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Publication Information
Korean Journal of Plant Resources / v.34, no.1, 2021 , pp. 31-36 More about this Journal
Abstract
Berchemia berchemiaefolia (Makino) Koidz. is found not only in korea, but also in japan and is known as a rare plant all over the world. In this study, we evaluated anti-inflammatory effect of B. berchemiaefolia (Makino) Koidz. leaves (BBK-L) in LPS-stimulated RAW264.7 cells. BBK-L inhibited the generation of NO through the suppression of iNOS experession. BBK-L attenuated the expression of iNOS, COX-2, TNF-α, IL-1β, IL-6 induced by LPS. BBK-L decreased LPS-mediated IκB-α degradation inhibite which resulted in the inhibition of NF-κB activation in RAW264.7 cells. In addition, BBK-L suppressed ERK1/2, JNK phosphorylation induced by LPS. BBK-L showed anti-inflammatory effect through blocking the generation of the inflammatory mediators such as NO, iNOS, COX-2, TNF-α, IL-1β, IL-6 via the inhibiting of NF-κB and MAPK signaling activation. These results suggests that BBK-L may have great potential for the development of anti-inflammatory drug to treat acute and chronic inflammatory disorders.
Keywords
Anti-inflammatory activity; Berchemia berchemiaefolia Koidz; Pro-inflammatory cytokine;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Atreya, R. and M.F. Neurath. 2005. Involvement of IL-6 in the pathogenesis of iflammatory bowel disease and colon cancer. Clin. Rex. Allergy Immunol. 28:187-196.   DOI
2 Boumpas, D.T., G.P. Chrousos and R.L wilder. 1993. Glucocorticoid therapy for immune mediated disease: Casic and clinical correlates. Ann. Intern. Med. 119:1198-208.   DOI
3 Chang, C.S., H.S. Lee, T.Y. Park and H. Kim. 2005. Reconsideration of rare and endangered plant species in Korea based on the IUCN red list categories. Korean J. Ecology 28:305-320.   DOI
4 Chi, H.J. 1998. Anticancer herb from Korean medicinal plants. Korean J. Plant Res. 2:1-17.
5 Choi, S.C., M.H. Joo and G.H. Lee. 2015. The influence of Korean Berchemia berchemiaefolia (Makino) Koidz extract on nonalcoholic hepatic steatosis in rats. AJMAHS 5:131-142.   DOI
6 Coskun, M., J. Olsen, J.B. Seidelin and O.H Nielsen. 2011. MAP kinases in inflammatory bowel disease. Clin. Chim. Acta. 412(7-8):513-520.   DOI
7 Guha, M. and N. Mackman. 2001. LPS induction of gene expression in human monocytes. Cell Signal. 13(2):85-94.   DOI
8 Guzik, T.J., R. Korbut and T. Adamek-Guzik. 2003. Nitric oxide and superoxide in inflammation and immune regulation. J. Physiol. Pharmacol. 54:469-487.
9 Hsieh, C.Y., M.J. Hsu, G. Hsiao, Y.H. Wang, C.W. Huang, S.W. Chen, T. Jaya-kumar, P.T. Chiu, Y.H. Chiu and J.R. Sheu. 2011. Andrographolide enhances nuclear factor-kB subunit p65 Ser 536 dephosphorylation through activation of protein phosphatase 2A in cascular smooth muscle cells. J. Biol. Chem. 286:5942-5955.   DOI
10 Ilorton, J.K., A.S. Williams, Z. Smith-Philips, R.C. Martin and G. O'Beirne. 1999. Intracellular measurement of prostaglandin E2 : Effects of anti-inflammatory drugs on cyclooxygenase activity and prostanoid expression. Anal. Biochem. 271:18-28.   DOI
11 Jin, B.M., G.H. Lee and K.Y. Hyun. 2014. Antidepressant-like effects of Berchemia berchemiaefolia via NF-κB signal transduction in rat models of depression. AJMAHS 4(2):79-90.   DOI
12 Kim, J.D., S.B. Park, H.J. Eo, G.H. Park and J.B. Jeong. 2020. Induction of apoptosis by Sageretia thea branch extracts through activation of NF-κB signaling pathway in human colorectal cancer cells. Korean J. Plant Res. 33(5):428-435.   DOI
13 Lee, H. J., E.A. Hyun, W.J. Yoon, B.H. Kim, M.H. Rhee, H.K. Kang, J.Y, Cho and E.S. Yoo. 2006. In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts. J. Ethnopharmacology 103:208-216.   DOI
14 Rabson, A., I.M. Roitt and P.J. Delves. 2005. Really Essential Medical Immunology. Blackwell Publishing Ltd., Hoboken, NJ (USA). pp. 1-14.
15 Lee, J.H., C.W. Yun and S.C. Hong. 2005. Community and population structure of Berchemia berchemiaefolia Forest. Korean J. For. Soc. 94(4):269-274.
16 Moynagh, P.N. 2005. The NF-kappa B pathway. J. Cell Sci. 118:4589-92.   DOI
17 Namkoong, S., S.A. Jang, E.H. Sohn, J.P. Bak, E. Sohn, H.J. Koo, W.J. Yoon, J.E. Kwon, Y.J. Jeong, X. Meng, H.S. Han and S.C. Kang. 2015. Comparative study of Litsea japonica leaf and fruit extract on the anti-inflammatory effects. Korean J. Plant Res. 28(2):145-152.   DOI
18 Shin, J., S., J.M. Kim and W.G. An. 2012. Anti-inflammatory effect of red ginseng through regulation of MAPK in lipopolysaccharide-stimulated RAW264.7. J. Physiol. Pathol. Korean Med. 26:293-300.
19 Sim, M.O., H.J. Lee, J.H. Jang, H.E. Lee, H.K. Jung, T.M. Kim, J.H No, J. Jung, D.E Jung and H.W. Cho. 2017. Anti-inflammatory and antioxidant effects of Spiraea prunifolia Sieb. Et Zucc. var. simpliciflora Nakai in RAW 264.7 cells. Korean J. Plant Res. 30:335-342.   DOI
20 Wang, Y., J. Xu, Y. Meng, I.M. Adcock and X. Yao. 2018. Role of inflammatory cells in airway remodeling in COPD. Int J. Chron. Obstruct. Pulmon. Dis. 13:3341-3348.   DOI
21 Zhang, Y., T. Pizzute and M. Pei. 2014. A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration. Cell Tissue Res. 358(3):633-649.   DOI