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http://dx.doi.org/10.7732/kjpr.2020.33.5.467

Vasodilatation effect of Kirenol isolated from Sigesbeckia pubescens  

Nam, Jung Hwan (Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration)
Publication Information
Korean Journal of Plant Resources / v.33, no.5, 2020 , pp. 467-475 More about this Journal
Abstract
The purpose of this study is to investigate the vasodilatation effect of kirenol isolated from Sigesbeckia pubescens on the rabbit basilar artery. In this study, to determine the vasodilatation effect of kirenol on the rabbit basilar artery, arterial rings with intact or damaged endothelium were used for the experiment. And used an organ bath and force transducer were contracted by endothelin. Kirenol, major active constituents of S. pubescens, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with kirenol may selectively accelerate cerebral blood flow through dilatation of the basilar artery. This result suggests a potential role of kirenol isolated from S. pubescens as a source of vasodilatation agent.
Keywords
Basilar artery; Endothelin; Kirenol; Sigesbeckia pubescens; Vasodilatation;
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