Browse > Article
http://dx.doi.org/10.7732/kjpr.2020.33.5.460

Inhibitory Effect of the Rodgersia podophylla Leave Extracts against Cell Proliferation through Activation of NF-κB in Human Colorectal Cancer Cells  

Kim, Jeong Dong (Department of Medicinal Plant Resources, Andong National University)
Jeong, Jin Boo (Department of Medicinal Plant Resources, Andong National University)
Publication Information
Korean Journal of Plant Resources / v.33, no.5, 2020 , pp. 460-466 More about this Journal
Abstract
In this study, we evaluated the anti-cancer activity and potential molecular mechanism of 70% ethanol extracts of leaves from Rodgersia podophylla against human colorectal cancer cells, HCT116. RPL dose-dependently decreased the cell viability through RPL-induced apoptosis in HCT116 cells. RPL induced inactivation the nuclear factor κB(NF-κB) through blocking IκB-α degradtion and P65 nuclear accumulation. The inhibition of GSK3β by LiCl attenuated RP-L-mediated NF-κB signaling inactivation. In addition, RP-L induced GSK3β activation. Based on these findings, RPL may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer.
Keywords
Anticancer activity; $NF-{\kappa}B$ signaling pathway; Rodgersia podophylla;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Arnold, M., M.S. Sierra, M. Laversanne, I. Soerjomataram, A. Jemal and F. Bray. 2017. Global patterns and trends in colorectal cancer incidence and mortality. Gut 66:683-691.   DOI
2 Chin, Y.W., E.Y. Park, S.Y. Seo, K.D. Yoon, M.L. Ahn, Y.G. Suh, S.G. Kim and J. Kim. 2006. A novel iNOS and COX-2 inhibitor from the aerial parts of Rodgersia podophylla. Bioorg. Med. Chem. Lett. 16:4600-4602.   DOI
3 Dolcet, X., D. Llobet, J. Pallares and X. Matias-Guiu. 2005. NF-${\kappa}B$ in development and progression of human cancer. Virchows Arch. 446:475-482.   DOI
4 Jeong, J.B., X. Yang, R. Clark, J.E. Choi, S.J Baek and S.H. Lee. 2013. A mechanistic study of the proapoptotic effect of tolfenamic acid: Involvement of NF-${\kappa}B$ activation. Carcinogenesis 34:2350-2360.   DOI
5 Kim, H.N., J.D. Kim, H.J Son, G.H. Park, H.J. Eo and J.B. Jeong. 2019. Anti-cancer activity of the leave extracts of Rodgersia podophylla through ${\beta}$-catenin proteasomal degradation in human cancer cells. Korean J. Plant Res. 32(5):442-447.
6 Kim, H.N., J.D. Kim, S.B. Park, H.J Son, G.H. Park, H.J. Eo, H.S. Kim and J.B. Jeong. 2020. Anti-inflammatory activity of the extracts from Rodgersia podophylla leaves through activation of Nrf2/HO-1 pathway, and inhibition of NF-${\kappa}B$ and MAPKs pathway in mouse macrophage cells. Inflamm. Res. 69:233-244.   DOI
7 Meyerhardt, J.A. and R.J. Mayer. 2005. Systemic therapy for colorectal cancer. N. Engl. J. Med. 352:476-87.   DOI
8 Park, B.K., J.H. Lee, C.K. Cho, H.K. Shin, S.K. Eom and H.S. Yoo. 2008. Systemic review of clinical studies about oriental medical treatment of cancer in Korea. Korean J. Orient. Int. Med. 29(4):1061-1074.
9 Wang, H., T.O. Khor, L. Shu, Z. Su, F. Fuentes, J.H. Lee and A.N.T. Kong. 2012. Plants against cancer: A review on natural phytochemicals in preventing and treating cancers and their druggability. Anti-Cancer Agents Med. Chem. 12: 1281-1305.   DOI
10 Wyllie, A.H., G.J. Beattie and A.D. Hargreaves. 1981. Chromatin changes in apoptosis. Histochem. J. 13:681-692.   DOI
11 Zhang, S., C.N. Ong, H.M. Shen. 2004. Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett. 208:143-153.   DOI