Browse > Article
http://dx.doi.org/10.7732/kjpr.2020.33.5.428

Induction of Apoptosis by Sageretia thea Branch Extracts through Activation of NF-κB Signaling Pathway in Human Colorectal Cancer Cells  

Kim, Jeong Dong (Department of Medicinal Plant Resources, Andong National University)
Park, Su Bin (Department of Medicinal Plant Resources, Andong National University)
Eo, Hyun Ji (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Park, Gwang Hun (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Jeong, Jin Boo (Department of Medicinal Plant Resources, Andong National University)
Publication Information
Korean Journal of Plant Resources / v.33, no.5, 2020 , pp. 428-435 More about this Journal
Abstract
In this study, we evaluated the inhibitory effect against cell growth and potential molecular mechanism of 100% ethanol extracts of branch from Sageretia thea in human colorectal cancer cells, HCT116. Ethanol dose-dependently extracts of STB significantly suppressed the growth of HCT116 cells through apoptosis. STB activated NF-κB signaling pathway through IκB-α proteasomal degradation and inducing p65 accumulation in nucleus. The inhibition of GSK3β by LiCl didn't affect STB mediated degradation IκB-α but STB mediated p65 accumulation in nucleus. In addition, STB phosphorylated GSK3β. Based on these findings, STB may be a potential candidate for the development of anti-cancer agents for human colorectal cancer.
Keywords
Apoptosis; Cancer chemoprevention; Colorectal cancer; $NF-{\kappa}B$ signaling; Sageretia thea;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Bi, X., Q. Lin, T.W. Foo, S. Joshi, T. You, H.M. Shen, C.N. Ong, P.Y. Cheah, K.W. Eu and C.L. Hew. 2006. Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways. Mol. Cell. Proteom. 5(6):1119-1130.   DOI
2 Bours, V., M.B. Alj, A.C. Hellin, P. Viatour, P. Robe, S. Delhalle, V. Benoit and M.P. Merville. 2000. Nuclear factor-${\kappa}B$, Cancer, and Apoptosis. Biochem. Pharmacol. 60:1085-1090.   DOI
3 Bray, F., J. Ferlay, I. Soerjomataram, R.L. Siegel, L.A. Torre and A. Jemal. 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68:394-424.   DOI
4 Cheng, Y.Y., C.H. Hsieh, T.H. Tsai. 2018. Concurrent administration of anticancer chemotherapy drug and herbal medicine on the perspective of pharmacokinetics. J. Food Drug Anal. 26:S88-S95.   DOI
5 Dolcet, X., D. Llobet, J. Pallares and X. Matias-Guiu. 2005. NF-${\kappa}B$ in development and progression of human cancer. Virchows Arch. 446:475-482.   DOI
6 Hassanzadeh, P. 2011. Colorectal cancer and NF-${\kappa}B$ signaling pathway. Gastroenterol. Hepatol. Bed Bench 4(3):127-132.
7 Hoeflich, K.P., J. Luo, E.A. Rubie, M.S. Tsao, O. Jin and J.R. Woodgett. 2000. Requirement for glycogen synthase kinase-3 ${\beta}$ in cell survival and NF-${\kappa}B$ activation. Nature 406:86-90.   DOI
8 Hyun, T.K., S.C. Song, C.K. Song and J.S. Kim. 2015. Nutritional and nutraceutical characteristics of Sageretia theezans fruit. J. Food Drug Anal. 23:742-749.   DOI
9 Irmak, Z., O. Tanriverdi, H. Odemis and D.D. Uysal. 2019. Use of complementary and alternative medicine and quality of life of cancer patients who received chemotherapy in Turkey. Complement. Ther. Med. 44:143-150.   DOI
10 Jeong, J.B., X. Yang, R. Clark, J.E. Choi, S.J Baek and S.H. Lee. 2013. A mechanistic study of the proapoptotic effect of tolfenamic acid: involvement of NF-${\kappa}B$ activation. Carcinogenesis 34(10):2350-2360.   DOI
11 Jung, K.W., Y.J. Won, H.J. Kong and E.S. Lee. 2018. Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2015. Cancer Res. Treat. 50(2):303-316.   DOI
12 Kole, L., B. Giri, S.K. Manna, B. Pal and S. Ghosh. 2011. Biochanin-A, an isoflavone, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NF${\kappa}B$ nuclear translocation. Eur. J. Pharmacol. 653:8-15.   DOI
13 Kim, H.N., G.H. Park, J.D. Kim, S.B. Park, H.J. Eo and J.B. Jeong. 2019a. Effect of the extracts from the leaves and branches of Sageretia thea on ${\beta}$-catenin proteasomal degradation in human colorectal and lung cancer cells. Korean J. Plant Res. 32(2):153-159.   DOI
14 Kim, H.N., G.H. Park, S.B. Park, J.D. Kim, H.J. Eo, H.J. Son, J.H. Song and J.B. Jeong. 2019b. Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells. BMC Complement. Altern. Med. 19:43.   DOI
15 Kim, H.N., G.H. Park, S.B. Park, J.D. Kim, H.J. Eo, H.J. Son, J.H. Song and J.B. Jeong. 2019c. Sageretia thea inhibits inflammation through suppression of NF-${\kappa}B$ and MAPK and activation of Nrf2/HO-1 signaling pathways in RAW264.7 cells. Am. J. Chin. Med. 47(2)385-403.   DOI
16 Lin, Y., L. Bai, W. Chen, and S. Xu. 2010. The NF-${\kappa}B$ activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin. Ther. Targets 14(1):45-55.   DOI
17 Meyerhardt, J.A. and R.J. Mayer. 2005. Systemic therapy for colorectal cancer. N. Engl. J. Med. 352:476-87.   DOI
18 Perkins, N.D. and T.D. Gilmore. 2006. Good cop, bad cop: The different faces of NF-${\kappa}B$. Cell Death Differ. 13:759-772.   DOI
19 Moon, S.M., S.A. Lee, J.H. Hong, J.S. Kim, D.K. Kim and C.S. Kim. 2018. Oleamide suppresses inflammatory responses in LPS-induced RAW264.7 murine macrophages and alleviates paw edema in a carrageenan-induced inflammatory rat model. Int. Immunopharmacol. 56:179-185.   DOI
20 Park, S.B., G.H. Park, Y.R. Um, H.N. Kim, H.M. Song, N.H. Kim, H.S. Kim and J.B. Jeong. 2018. Wood-cultivated ginseng exerts anti-inflammatory effect in LPS-stimulated RAW264.7 cells. Int. J. Biol. Macromol. 116:327-334.   DOI
21 Pfeffer, C.M. and A.T.K. Singh. 2018. Apoptosis: A target for anticancer therapy. Int. J. Mol. Sci. 19(2):448.   DOI
22 Wang, H., T.O. Khor, L. Shu, Z. Su, F. Fuentes, J.H. Lee and A.N.T. Kong. 2012. Plants against cancer: A review on natural phytochemicals in preventing and treating cancers and their druggability. Anti-Cancer Agents Med. Chem. 12:1281-1305.   DOI
23 Wyllie, A.H., G.J. Beattie and A.D. Hargreaves. 1981. Chromatin changes in apoptosis. Histochem J. 681-692.
24 Yaghoubi, N., A. Soltani, K. Ghazvini, S.M. Hassanian and S.I. Hashemy. 2019. PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer. Biomed. Pharmacother. 110:312-318.   DOI
25 Yun, S.I., H.Y. Yoon, S.Y. Jeong and Y.S. Chung. 2009. Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase $3{\beta}$. J. Bone Miner. Metab. 27:140-148.   DOI
26 Arghi, M., I. Soerjomataram, M. Jenkins, J. Brierley, E. Morris, F. Bray and M. Arnold. 2019. Global trends in colorectal cancer mortality: Projections to the year 2035. Int. J. Cancer. 144:2992-3000.   DOI