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http://dx.doi.org/10.7732/kjpr.2019.32.6.698

Anti-inflammatory Effect of Branches Extracts from Quercus mongolica in LPS-induced RAW264.7 Cells  

Eo, Hyun Ji (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Park, Youngki (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Kang, Jin Taek (Division of Forest Industry Research, National Institute of Forest Science)
Park, Gwang Hun (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Publication Information
Korean Journal of Plant Resources / v.32, no.6, 2019 , pp. 698-704 More about this Journal
Abstract
Quercus mongolica (QM), which belongs to fagaceae, is one of the oak native to Korea. We evaluated the anti-inflammatory effect of branches extracted with 70% ethanol of QM (QM-B) and elucidated the potential signaling pathway in LPS-induced RAW264.7 cells. The QM-B showed anti-inflammatory activity through inhibition of NO production. The QM-B dose-dependently suppressed NO production by inhibiting iNOS, COX-2 and IL-6 expression in LPS-induced RAW264.7 cells. The QM-B inhibited the degradation and phosphorylation of IκB-α and NF-κB activation. The QM-B suppressed the phosphorylation of p38 and ERK1/2. Also, the QM-B increased HO-1 expression. These results suggested that QM-B may utilize anti-inflammatory activity by suppressing NF-κB and MAPK signaling pathway and inducing HO-1 expression indicated that the QM-B can be used as a natural anti-inflammatory drugs.
Keywords
Anti-inflammatory effect; HO-1; MAPK; $NF-{\kappa}B$; Quercus mongolica;
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Times Cited By KSCI : 4  (Citation Analysis)
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